The Indiana CTSI Biomedical Engineering and Bionanomedicine Program (BEAN) enables investigators to develop technologies and speed their progress towards clinical implementation.
The BEAN Program combines technical, pre-clinical and industrial expertise from the Weldon School of Biomedical Engineering, the College of Veterinary Medicine at Purdue University and IU School of Medicine.
- Facilitate access to biomedical engineering and bionanotechnology capabilities at Purdue University.
- Assist investigators with preclinical and clinical trial planning early in the device development process.
- Foster investigator partnerships with regional device manufacturing companies, and subsequent widespread patient access to these technologies.
- Diminish the gap between engineering discovery and clinical impact.
Extensive expertise and support are available in five inter-related domains:
Medical Device Design, Prototyping, and Evaluation
The Weldon School of Biomedical Engineering at Purdue has a long and productive history in the design and development of medical devices for a wide array of clinical applications. With in-house capabilities for materials and electronics fabrication and extensive experience that includes electronic, optical, and mechanical instrumentation; noise analysis and remediation; design and fabrication of measurement systems; electrodes; sensors; tissue stimulation and response; implantable electronics; and, experiment and protocol design and logistics, the team can provide a wide range of research and development services.
Bionanotechnology Approaches and Therapeutics Development
Bionanotechnology resources span laboratories in five schools at Purdue and focus on three core areas: construction of therapeutic vehicles in scales ranging from nano to macro; development and testing of therapeutic molecules with controlled and targeted delivery; and, integration and testing of cell-material interactions at the in-vitro and in-vivo levels.
The design, construction, and testing of new drug delivery systems involve an integration of the above three general areas of bionanotechnology. A full BME graduate level course, also available as an online version on the NSF-funded nanoHUB in the Birck Nanotechnology Center, describes the full-scale integration of these technologies and methods which provide a roadmap for both faculty and students exploring all of these systems.
Preclinical Studies Planning, Coordination, and Implementation
The preclinical studies team at the Purdue Weldon School of Biomedical Engineering collaborates with investigators and provides expertise, resources, and assistance in conducting preclinical studies in a wide variety of animal models and procedures. Technical services available include, but are not limited to:
- Preview of protocol applications prior to submission
- Pre-study consultation
- Training support
- Pre-surgical and surgical animal study preparation
- Access to imaging services
- Aftercare of animals in recovery studies
- Post-surgical questions/care
The Clinical Discovery Laboratory (CDL) of the Department of Veterinary Clinical Sciences (VCS) is one of the resources available. The CDL is part of the Medical Discovery Resource Unit (MDRU) and is a multidisciplinary laboratory where VCS faculty members collaboratively conduct advanced clinical and applied research using induced animal models.
Veterinary Clinical Trials
The Clinical Trials Group (CTG) is part of the College of Veterinary Medicine Medical Discovery Resource Unit. The Clinical Trials Group facilitates animal clinical trials within the Purdue Veterinary Teaching Hospital and provides expertise and technical support for translational clinical investigations using spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices for use in companion and food animals. Patients are actively recruited for clinical trial research in the ongoing effort to improve the care and treatment of all animals, large and small.
View the full list of current clinical trials to learn more.
Histology and Phenotyping
The Histology Laboratory is a division of the Center for Comparative Translational Research at the Purdue College of Veterinary Medicine. The lab, designed to assist Purdue and outside scientists in their preclinical and discovery translational research efforts, is staffed by two full-time technicians. Submitted tissue samples are embedded in paraffin, plastic or OCT medium (frozen tissue). Embedded tissues are sectioned with a rotary microtome (paraffin and plastic), cryostat (frozen tissues), or with EXAKT grinding (plastic embedded undecalcified bone and implants). A variety of histological stains is available and automated immunocytochemistry services are offered.Veterinary pathologists with experience in device associated pathology, drug and toxicologic pathology and infectious disease pathology are available to collaborate and consult on projects.