Service Cores

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Service Cores

Indiana CTSI Research Service Cores and Resources

The Indiana CTSI Research Service Cores and Resources are your aid to locate instrumentation and services suited to your research. A listing of a Core’s capabilities, contact information, and website address can be found by clicking their ‘Learn More’ button. All of the Designated Service Cores are eligible for CTSI Core Pilot grants and Post-Doc grants
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IU Indianapolis

Designated Service Core

Behavioral Phenotyping Core (BPC)

The BPC advises upon and/or conducts behavioral experiments in rats or mice. Assays include assessments of general sensory and motor function, cognitive processing, affective reactivity, and PK/PD relationships in drug evaluations.

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IU Indianapolis

Designated Service Core

Bioinformatics Core

The Bioinformatics Core provides advanced computation and informatics approaches to analyze large and complex biological datasets.

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Purdue University

Non-Designated Service Resource

Bioinformatics Core

The Bioinformatics Core provides data analysis services for genomics, proteomics and metabolomics data.

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Purdue University

Designated Service Core

Biological Evaluation (BE-SR)

The Biological Evaluation Shared Resource performs highly customizable efficacy testing of novel drug or therapies for antitumor activity. We also acquire blood or tissues for pharmacokinetic or pharmacodynamic analyses.

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IU Indianapolis

Non-Designated Service Resource

Biomedical and Health Research Services

Provide software and technology solutions for research, especially for projects that involve electronic protected health information (ePHI).

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IU Indianapolis

Designated Service Core

Biospecimen Collection and Banking Core

The IUSCCC Biospecimen Collection and Banking Core (BC2) provides an extensive collection of well-annotated samples from patients with malignancy and normal controls to support studies exploring the biologic basis of cancer, move basic findings to the clinic, and probe the biology underlying clinical and population phenomena. 

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IU Indianapolis

Designated Service Core

Biospecimen Management Core (CTSL/SSF)

The CTSI Biospecimen Management Core consists of the Specimen Storage Facility (SSF) and the Clinical and Translational Support Laboratory (CTSL), which together offer cost efficient sample processing & storage services with a focus on consistent quality and sample integrity.

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IU Indianapolis

Designated Service Core

Biostatistics and Health Data Science Core

The Biostatistics and Health Data Science Core collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. Grant development assistance is provided without charge.

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IU Bloomington

Designated Service Core

Biostatistics Consulting Center

The Biostatistics Consulting Center provides study design and data analysis for health-related research, including study design, grant or protocol development, sample size and power calculations, data management, data analysis, and scientific writing. Support can range from hourly support on a short-term project to including a biostatistician on a long-term grant collaboration.

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IU Indianapolis

Designated Service Core

Cellular Response Technologies Core

Conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders. The ABC also manages an IncuCyte Zoom and Seahorse XFp.

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IU Bloomington

Non-Designated Service Resource

Center for Evaluation, Policy, and Research (CEPR)

CEPR provides rigorous, high-quality, non-partisan evaluation, policy analyses, and research for meaningful, useful, and actionable data for clients and project stakeholders. Clients include international, federal and state agencies, public and private organizations, and foundations and endowments working across a range of fields and disciplines.

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IU Bloomington

Designated Service Core

Center for Genomics and Bioinformatics (CGB)

The CGB offers a wide range of genomic services, including high-throughput DNA/RNA extraction, library preparation, next-generation sequencing, and bioinformatic analysis.

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IU Indianapolis

Designated Service Core

Center for Medical Genomics (CMG)

The Center for Medical Genomics provides high-throughput genomics services including: genomic DNA sequencing, transcriptome RNA sequencing, miRNA sequencing, methylome or targeted methylation sequencing, protein DNA/RNA interaction (ChIP-seq, ATAC-seq and CLIP-seq), 10x single cell or single nuclei sequencing, and SNP genotyping.

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IU Bloomington

Designated Service Core

Center for Survey Research (CSR)

Leading academic research center providing expert research design, sampling, questionnaire design, interface development and programming, data collection, data processing, and analysis services for wide range of qualitative and quantitative research projects. Partnering on cutting-edge research that involves surveys, interviews, focus groups, or structured observations.

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IU Indianapolis

Designated Service Core

Chemical Genomics Core Facility

The CGCF is located in the Van Nuys Medical Science Building in Indianapolis. The core is equipped with five hoods for chemical synthesis, a microwave reactor, a parallel synthesizer and preparative HPLCs, LC-QTOF and 600 MHz NMR; a collection of 227,680 diversified small molecules, CRISPR libraries, liquid handling, assay detection and cell image systems.

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IU Indianapolis

Designated Service Core

Clinical Pharmacology Analytical Core (CPAC)

The Clinical Pharmacology Analytical core provides drug and metabolite concentrations from a variety of biological matrices such as (but not limited to): plasma, urine, CSF, and tissue using HPLC-MS/MS. Additional services include protein binding of drugs, formulation studies, drug stability, drug metabolism, and metabolite screening.

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Purdue University

Designated Service Core

Cryo-EM Facility

The Purdue Cryo-EM facility provides access to state-of-the-art instrumentation enabling users to collect data for high-resolution single particle reconstructions and tomographic studies of cells and larger complexes.

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IU Indianapolis

Non-Designated Service Resource

Electrophysiology Core

The Electrophysiology Core performs rodent brain slice electrophysiological recordings to measure brain cell function.

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Notre Dame

Designated Service Core

Genomics and Bioinformatics Core Facility (GBCF)

The Genomics & Bioinformatics Core Facility (GBCF) at the University of Notre Dame offers comprehensive services and support for state-of-the-art genomics experiments and bioinformatics analysis. This includes next generation Illumina sequencing, a variety of standard and specialty DNA and RNA library construction methods, consultation, and analysis support.

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IU Indianapolis

Non-Designated Service Resource

HANDS In Autism Interdisciplinary Training & Resource Center

The HANDS (Helping Answer Needs by Developing Specialists) in Autism® Interdisciplinary Training & Resource Center is located within the Department of Psychiatry at the Indiana University School of Medicine. The HANDS team offers services including:
(1) recruitment,
(2) behavioral, educational, functional, and/or vocational assessment of individuals across a broad range of ages and functioning levels, and
(3) program evaluation efforts targeted to a range …

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IU Indianapolis

Designated Service Core

Histology and Histomorphometry Core (HHC)

Histology and Histomorphetry Core (HHC) provides histological and histomorphometric services for basic science (non-clinical) research. Mineralized (plastic embedded), soft tissue (paraffin embedded), and cryopreserved specimens can be processed by the facility.

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Purdue University

Designated Service Core

Histology Research Laboratory (HRL)

The Histology Research Laboratory is a full service histology laboratory that provides general histology, immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. Board certified veterinary pathologists are also available for consultation.

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Purdue University

Designated Service Core

Imaging Facility

The Bioscience Imaging Facility, Purdue University, is a 24hr/7day access core facility specializing in confocal microscopy, multi-photon and light sheet microscopy, pre-clinical molecular and nuclear imaging and computed tomography (mCT) with offline analysis workstations.

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IU Indianapolis

Designated Service Core

In-Vivo Imaging Core

The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …

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Notre Dame

Designated Service Core

Integrated Imaging Facility (NDIIF)

The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core that makes available to the Notre Dame science and engineering community, as well as external customers, an integrated suite of sophisticated microscopes and imaging stations. The NDIIF also provides resident professional staff (three Ph.D.-level imaging specialists and two technicians) to guide the non-expert users. 

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IU Indianapolis

Designated Service Core

Islet and Physiology Core

The Islet and Physiology Core of the Center for Diabetes and Metabolic Diseases provides investigators with the capability to obtain high quality rodent pancreatic islets for study.  The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. 

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IU Indianapolis

Designated Service Core

IU School of Medicine Center for Electron Microscopy (iCEM)

The Indiana University School of Medicine Electron Microscopy Center is a full service research laboratory providing both Transmission and Scanning Electron Microscopy. The service provided can apply both traditional methods and recent technical developments to suit the investigator’s needs.

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IU Bloomington

Designated Service Core

Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)

The Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.

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Notre Dame

Designated Service Core

Magnetic Resonance Research Center

The Magnetic Resonance Research Center (MRRC) supports research in chemistry, biochemistry, molecular biology, engineering and related fields. The MRRC operates six solution-state NMR spectrometers (400 to 800 MHz), a solid-state 300 MHz NMR instrument, and an X-band EPR spectrometer. Most instruments are equipped with sample changers for increased sample throughput. See the MRRC website for more information.

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Notre Dame

Non-Designated Service Resource

Molecular Structure Facility

The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.

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Purdue University

Designated Service Core

Pre-Clinical Research Laboratory (PCL)

The Pre-Clinical Research Laboratory (PCL) helps researchers conduct pre-clinical animal research by providing research expertise, technical support, surgical experience, and surgical facilities and equipment. The PCL is a multidisciplinary laboratory where researchers conduct advanced clinical and applied research using induced animal models ranging from rodents to pigs and sheep

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IU Indianapolis

Non-Designated Service Resource

Preclinical Innovation Think Tanks

Indiana CTSI Think Tanks are an opportunity for researchers at any of the Indiana CTSI campuses of Indiana University (IU), Purdue University and the University of Notre Dame to get help advancing their discoveries to the market. The Drug and Device Think Tanks each serve as a one-stop shop where investigators can receive guidance from a pool of advisors with a wide range of scientific, technical, clinical, business, and regulatory expertise.

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Purdue University

Designated Service Core

Proteomics Facility

The Purdue Proteomics Facility provides chromatography, mass spectrometry and bioinformatic resources for the research communities on campus and beyond for protein characterization. These services include protein identification, relative and absolute quantitation, mapping post-translational modifications, and discovering new protein complexes and protein-protein interactions from a wide variety of sample types such as gel bands, cell or tissue lysates, and plasma or …

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IU Indianapolis

Designated Service Core

Regenstrief Data Services

Services RDS offerings include, but are not limited to:

• Feasibility
• DIY: i2b2
• Cohorts
• Recruitment Lists
• Registries
• Patient Lists
• Geocoding
• Phenotyping
• Deidentification
• EHR Integration/Innovation
• Application Development
• Application Prototypes
• Natural Language Processing (NLP)
• Data Linkage
• Machine Learning Models …

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IU Indianapolis

Designated Service Core

Translation Core

The Translation Core provides services that facilitate the conduct of research involving human subjects, including supplying low-cost, high-quality analyte measurements for a variety of hormones, cytokines, lipids and other analytes. Translation Core human studies services include phenotyping (i.e. GTT, clamp studies, tracer studies), and access to a biobank of human tissues and serum.

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Purdue University

Designated Service Core

Translational Pharmacology Facility

The PTP Core offers automated blood monitoring in rodents and large animals utilizing stress free sampling through CulexTM technology. We perform a host of services from early lead identification PK and PD assessment through product testing of human formulations in pigs and minipigs, including preclinical formulation development, biodistribution studies, metabolomics analysis, and in vivo toxicological evaluation.

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Purdue University

Non-Designated Service Resource

Veterinary Clinical Trials (VCT)

The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices.

|2024-03-28T10:47:31-04:00March 28th, 2024|Comments Off on Service Cores

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