Affiliation(s): Indiana University
Samir K Gupta
Cardiovascular disease (CVD) is the leading cause of death in the United States. As such, research is clearly needed to better understand the pathophysiology of CVD, reduce the incidence of CVD, and limit the consequences of CVD. However, epidemiologic and therapeutic studies that rely on the endpoint of actual CVD events are generally expensive and cumbersome; thus, such studies are usually prohibitive. Therefore, surrogate markers of CVD have increasingly been used in research. Physiologic and anatomic vascular imaging measures can provide both mechanistic and predictive information to help guide research and better inform the eventual studies on ‘hard endpoints’ that are needed to improve CVD health. The Human Vascular Imaging Core will provide the following services: (1) flow-mediated dilation (FMD) of the brachial artery – a measure of endothelium-dependent vascular reactivity; (2) nitroglycerin-mediated dilation (NTGMD) of the brachial artery – a measure of endothelium-independent vascular reactivity; and (3) carotid intima media thickness (CIMT) – a measure of cumulative arterial injury. By grouping these services within one Core, the interested IUPUI investigator can more directly access one or more of these services and work closely with the Core’s staff in choosing which services are most helpful for their particular research needs.
- This core currently provides the following services: (1) Brachial artery flow-mediated dilation (FMD); (2) Brachial artery nitroglycerin-mediated dilation (NTGMD); (3) Carotid artery intima media thickness (CIMT). User fees will be charged for studies that do not provide specific percent FTE support for use of Core services. These user fees/charge backs are based on personnel costs for the estimated times required to perform the listed procedures, service and maintenance costs, and reinvestment costs (for future capital equipment purchases/upgrades). There are no tiered rates for these services. For a full description of user fees, fee policies, and core policies (study participant confidentiality, priorititization of work, publication and authorship expectations, conflict resolution), please contact Dr. Gupta directly.
endothelium, cardiovascular, carotid intima media thickness , atherosclerosis, endothelial function
Samir K Gupta
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