Service Cores





CTSI Core Designation

Denotes a CTSI Designated Core. Investigators who wish to apply for CTSI Core Pilot Grants must apply to a CTSI Core to be eligible to receive these special grants.

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3D Bioprinting Core at IUSM/IUPUI (3DBPC)

Affiliation: IUSM / IUPUI

Director: Nicanor I. Moldovan, PhD

3D Bioprinting is a form of automated tissue engineering which produces cell-based structures useful for a variety of in vitro and in vivo applications. Our Core has been created around a leading-edge technology, called ‘scaffold-free bioprinting’ (one which does not need biomaterials as cell scaffolds). The Core is equipped with the “Bio 3D Printer Regenova” the most advanced instrument of this type in the world, and the first installed in USA in an academic institution. In addition, our users have access to the automated microscopy platform IncuCyte ZOOM which, besides other specialized cellular assays, performs analysis and optimization of cellular spheroids, the building blocks needed for the operation of the Regenova robot. Our Core provides training, as well as qualified assistance for all steps of the bioprinting process. We also help the users identify the best solutions for their research needs. By connecting the users with other specialized cores, we help them with imaging of the constructs and with other forms of analysis. For those interested, we may facilitate access to ‘scaffold-dependent’ bioprinting as well. We work with the users to implement this new technology in grant proposals and assist them to prepare the data for publication. We also have regular Core meetings, structured as an informative journal club and/or topic-oriented discussions, both for the newly initiated and for the experienced users.

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Nicanor I. Moldovan
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317-278-5191


Advanced Biomedical Information Technology Core

Affiliation: Pervasive Technology Institute (PTI), University Information Technology Services (UITS), IU School of Medicine (IUSM), Indiana CTSI, National Gene Vector Biorepository (NGVB)

Director: Robert Henschel
Manager: Richard Meraz

Supercomputing, medical informatics, applications software, massive storage and advanced visualization services, collaboration tools, Indiana CTSI HUB.

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Richard Meraz
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+1-317-274-3338


Angio BioCore (ABC)

Affiliation: IU Simon Cancer Center, IU School of Medicine, Wells Center for Pediatric Research

Director: Karen Pollok, Ph.D.

The ABC conducts validated and highly reproducible in vitro and in vivo assays systems in endothelial and hematopoietic progenitor cell biology. For more information about the ABC, please visit our home page by clicking the link above.

The ABC is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.

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Emily Sims
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317-278-7232


Bindley Bioscience Center

Affiliation: Purdue Discovery Park

Director: Richard Kuhn, Ph D.
Lab Manager: James Williams

Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.

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Bioinformatics Core

Affiliation: Center for Computational Biology and Bioinformatics, Department of Biochemistry & Molecular Biology, IU School of Medicine

Director: Yunlong Liu, Ph D.

Provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting.

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Dr. Yunlong Liu
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317-278-9222


Biological Evaluation Shared Resource Core

Affiliation: Purdue University

Director: Bennett D. Elzey, Ph.D.

In cancer biology, mouse models continue to play significant roles in studies of tumor invasion, metastasis and malignant transformation, as well as in studies examining responses to therapy. Key advancements have emerged in the development of animal models for cancer biology, including the advent of orthotopic models for metastasis, transgenic animals that have developmental pathways to tumorigenesis, and state-of-the-art immunocompromised strains. Transplanted human xenografts remain a primary tool for molecular discovery and evaluation. Despite their flaws and shortcomings, xenograft mouse models have played a significant role in cancer drug development in the past three decades, and mouse models will continue to be a foundation in the war against cancer.

At the Purdue University Center for Cancer Research (PCCR) where a vast pipeline of potential new agents for diagnosing and treating cancer are emerging, researchers need a productive and established facility for in vivo testing which can navigate the arena of murine cancer models. The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies to advance their projects using in vivo testing.

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Bennett Elzey, Ph.D.
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317-278-3449


Biophysical Analysis Laboratory (BAL)

Affiliation: Purdue University

Director: Jia Ma, PhD

The purpose of the BioAnalytical Lab at the Bindley Biosciences Center is to initiate long term productive collaborations and to provide a complete biophysical analysis of your sample. In the lab there are two analytical ultracentrifuges: Beckman-Coulter XLI and XLA, and a Biacore 3000 . With these instruments we can determine kinetic parameters, stoichiometry of binding, size distribution, shape, oligomerization state and other biophysical measurements. Complementing these traditional biophysical methods, the BioAnalytical Lab also provides mass spectrometric analyses at both the protein and peptide levels.

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Jia Ma
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765.496.6533


Biostatistics Consulting Center

Affiliation: Indiana University Bloomington

Core Director: Zhongxue Chen, Ph.D.
Associate Director: Stephanie Dickinson

The Biostatistics Consulting Center (BCC) is operated by the Department of Epidemiology and Biostatistics within the School of Public Health – Bloomington. The BCC is a research and service facility at Indiana University which provides a wide range of support and services through collaborative researches. We provide biostatistics and epidemiology consulting to IU faculty, research staff, graduate students, undergraduate students and non-university affiliated organizations or companies. Our mission is to provide our biostatistical and epidemiological expertise in support of health-related researches. Our team is comprised of Masters and PhD level statisticians and epidemiologists from the Department of Epidemiology and Biostatistics.

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Zhongxue Chen
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812-855-7580


Biostatistics Core

Affiliation: IU School of Medicine

Director: Barry Katz, Ph D.

Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development.

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(317) 274-2661


Birck Nanotechnology Center

Affiliation: Purdue Discovery Park

Director: James Leary

Nanometrology laboratories, complete suite of microelectronics and microfuidics fabrication and testing equipment, bio-pharma clean room.

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Monica Allain, Ph D.
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Center for Comparative Translational Research

Affiliation: Purdue University – College of Veterinary Medicine

Director: Gert J. Breur, DVM, MS, PhD, DACVS

Translational research spans the continuum in which research findings from the researcher’s lab are moved to the patients ‘bedside’ (human) or ‘barn’ (animal). The Center for Comparative Translational Research (CTR) wants to make bridging the gap between benchtop and bedside/barn easier by helping researchers conduct comparative animal studies using induced and spontaneous disease models. It does so by facilitating, coordinating, integrating and stimulating comparative translational discovery, learning and engagement. The Center has Purdue and CTSI core facilities for animal pre-clinical and clinical studies, and for histology and image digitization. These laboratories aid researchers with their work on diseases, drugs, biologics and medical devices.

The mission of the CTR is to support interdisciplinary research by providing the professional expertise (histology, pathology, imaging, investigative surgery, etc.) and facilities needed to support preclinical and translational biomedical investigation. Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.

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Gert Breur
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765-496-3487


Center for Evaluation and Education Policy (CEEP)

Affiliation: Indiana University – Bloomington, IU School of Education

Director: John H. Hitchcock, Ph.D

CEEP, Indiana’s leading program evaluation and education policy research center, promotes and supports rigorous program evaluation and education policy research for educational, human services, and nonprofit organizations. CEEP is interested in working with programs that promise real impact and improvement in education, the lives of children, and communities. Clients include federal and state agencies, public and private organizations, and foundations and endowments primarily working in the fields of public health, education, and youth development.

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John H. Hitchcock, Ph.D
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800-511-6575


Center for Medical Genomics

Affiliation: Indiana CTSI core, IU School of Medicine, Department of Biochemistry & Molecular Biology, Indiana Genomics Initiative (INGEN), Alcohol Research Center

Director: Yunlong Liu, PhD.
Associate Director: Xiaoling Xuei, PhD.

Provides genomic services including Next-generation sequencing, microarrays, targeted genotyping, allele-specific expression, methylation. Provides consultation for experimental design of genomics and genetics experiments, and related bioinformatics.

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Yunlong Liu, PhD
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Center for Nuclear Magnetic Resonance Spectroscopy

Affiliation: University of Notre Dame

Director: Jaroslav Zajicek, Ph D.

Molecular structure and dynamics determination from a wide variety of compounds.

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Jaroslav Zajicek, Ph D.
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(574) 631-9111


Center for Research Computing

Affiliation: University of Notre Dame

Director: Jarek Nabrzyski, Ph.D.

The CRC houses two complementary resources: the High Performance Computing section, providing over 20,000 cores of computational power with the associated support infrastructure for both hardware and installed software, and the Cyberinfrastructure section, empowering Faculty and industry partners to develop research environments that support advanced data and information processing services including acquisition, storage, management, integration, mining and visualization of data.

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(574) 631-2400


Center for Survey Research (CSR)

Affiliation: Indiana University

Core Director: Ashley Clark
Director, Research Project Management Services: Reya Calistes
Director, Research Data Management Services: Jamie Roberts
Director, Research Technologies: Joe Wilkerson
Director, R&D and Research Laboratory: Lilian Yahng

Provides expert research design, sampling, questionnaire design, interface development and programming, data collection, data processing, and analysis services for wide range of qualitative and quantitative research projects.

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Center for Survey Research
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(800) 258-7691


Center for Zebrafish Research

Affiliation: University of Notre Dame

Director: David Hyde, Ph D.

3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery.

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David Hyde, Ph D.
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(574) 631-8054


Chemical Genomics Core Facility

Affiliation: Department of Biochemistry & Molecular Biology, IU School of Medicine

Director: Thomas Hurley, Ph D.
Director of Chemistry and Informatics: Lifan Zeng, Ph D.
Director of High Throughput Screening: Jingwei Meng, Ph D.

Chemical Genomics Core Facility is located within Van Nuys Medical Science Building, IUSM. Equipped with a collection of 227,680 diversity-oriented, drug-like, and natural small molecules in 9 non-redundant libraries, a variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools.

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CISAB Mechanisms of Behavior Laboratory

Affiliation: IU Bloomington

Director: David Sinkiewicz

The Center for the Integrative Study of Animal Behavior (CISAB) at IU Bloomington strives to promote interdisciplinary research and academic interactions between faculty members, researchers, and students at IU who study animal behavior from diverse perspectives, including biology, psychology, neuroscience, and biological anthropology. As a key part of that mission, the CISAB Mechanisms of Behavior Lab provides individualized training, consultation, services, equipment and bench space, with special focus on services valuable to CISAB-affiliated researchers. While some lab users primarily utilize specialized shared-use equipment and wet lab space that can be found in the CISAB Mechanisms of Behavior lab, others conduct a wide variety of billable procedures that the Lab supports, with costs billed on a per-sample or per-plate basis. Currently supported techniques include hormone extraction, enzyme immunoassay (EIA/ELISA), nucleic acid extraction (including automated), PCR, gel electrophoresis, and quantitative PCR preparation.

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David Sinkiewicz
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812-856-1139


Clinical Pharmacology Analytical Core

Affiliation: Department of Medicine – Clinical Pharmocology Division, IU Simon Cancer Center, IU School of Medicine

Director: David R. Jones, Ph D.

Provides services to 1) assist in the quantification of drugs and/or metabolites, 2) identification of metabolites, and 3) pharmacokinetic analysis of data.

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David Jones, Ph D.
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(317) 278-3054


Drosophila Genomic Research Center

Affiliation: Indiana University at Bloomington

Director: Peter Cherbas, Ph.D.

Resource for comparative genomics, including development of transgenic flies with mutations in candidate human genes.

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Electron Microscopy Center

Affiliation: Department of Anatomy & Cell Biology, IU School of Medicine

Assistant Director: Caroline A. Miller

Provides electron microscopy services utilizing either scanning or transmission electron microscopy.

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Caroline A. Miller
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(317) 274-8730


Flow Cytometry Resource Facility

Affiliation: IU Simon Cancer Center, IU School of Medicine

Director: Edward Srour, Ph D.

The Flow Cytometry Facility provides essential and varied flow cytometric services to many IU Simon Cancer Center members at a reduced rate. The facility provides consultation, technical advice and collaboration, thus, promoting cutting-edge science and serving as a central common area for IU Simon Cancer Center investigators to interact and exchange scientific information.

The Flow Cytometry Facility is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.

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Edward Srour, Ph D.
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(317) 274-3589


Freimann Life Science Center

Affiliation: University of Notre Dame

Director: Satish Adusumilli, DVM, MVSc, PhD

30,000 sq. ft. state-of-the-art animal research facility. Fully accredited with highly trained, certified, professional staff.

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Satish Adusumilli
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(574) 631-5393


Genomics and Bioinformatics Core Facility

Affiliation: University of Notre Dame

Director: Mike Pfrender, Ph.D
Director of Bioinformatics: Scott Emrich, Ph.D
Assistant Director: Melissa Stephens

The Genomics and Bioinformatics Core Facility (GBCF) provides high quality services using state-of-the-art technology to conduct genomics experiments and bioinformatics analysis. GBCF services encompass a broad range of applications, including genomics (metagenomics, cancer, microbial, targeted, non-model), transcriptomics, and epigenomics. The facilities offer comprehensive support for a diverse research community that spans basic biomedical research in human disease, pathogen genomics, population genomics, and environmental genomics. The 1500 square foot genomics facility houses specialized equipment including an Illumina MiSeq and Illumina NextSeq 500 sequencers, Applied Biosystems 3730xl 96-capillary sequencer, Agilent 2100 Bioanalyzer, Affymetrix GeneChip System, Qubit 2.0 Fluorometer, BioRad CRX384 RT PCR system, Covaris S220 high-intensity acoustic shearing equipment, and Sage Science BluePippin. Our computing facilities are equipped with high performance hardware and computational resources. The GBCF has expertise in sequence assembly, next-generation sequence analysis, and parallel computing with developed pipelines for downstream data analysis of next-generation short-read sequencing data. These pipelines include image processing, base calling, genome and transcriptome assembly, reference mapping, SNP calling, and analyzing population genomic data.

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Mike Pfrender, Ph.D.
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(574) 631-0591


GLP Testing Facility

Affiliation: IUSOM

Director: Christie M. Orschell

Performs GLP mouse efficacy studies for radiomitigators.

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Christie M. Orschell
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HANDS in Autism

Affiliation: IUSM

Director: Naomi Swiezy, Ph.D., HSPP

The HANDS in Autism® Interdisciplinary Training and Resource Center was founded in 2004 as an extension of outreach and training offered at Riley Hospital for Children at IU Health and the IU School of Medicine. The vision of the HANDS in Autism® Center is to build local capacity through continuous learning and demonstrations of effective implementation of (1) evidence-based practices in supporting individuals with autism spectrum disorder and other neurodevelopmental and behavioral disorders across home, school, medical and other community settings and (2) regional community networks composed of same stakeholders bridging across systems and settings with a focus on shared responsibility for positive individual and family outcomes. Inherent in HANDS in Autism® practice and research is a focus on data-driven decision making, program evaluation and fidelity measurement in regards to effective implementation of identified best practices across settings.

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Tiffany Neal, Ph.D.
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274-2475


Histology Research Laboratory

Affiliation: Purdue University – Center for Comparative Translational Research – College of Veterinary Medicine

Director: L. Tiffany Lyle, DVM, PhD, DACVP

The Histology Research Laboratory is a full service histology laboratory that provides general histology (including special stains), immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. It also manages a large and small animal necropsy room. The laboratory may collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). Expertise in the processing of bone and implants is available.

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Tiffany Lyle
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(765) 494-9676


Human Vascular Imaging Core

Affiliation: Indiana University

Director: Samir K Gupta

Cardiovascular disease (CVD) is the leading cause of death in the United States. As such, research is clearly needed to better understand the pathophysiology of CVD, reduce the incidence of CVD, and limit the consequences of CVD. However, epidemiologic and therapeutic studies that rely on the endpoint of actual CVD events are generally expensive and cumbersome; thus, such studies are usually prohibitive. Therefore, surrogate markers of CVD have increasingly been used in research. Physiologic and anatomic vascular imaging measures can provide both mechanistic and predictive information to help guide research and better inform the eventual studies on ‘hard endpoints’ that are needed to improve CVD health. The Human Vascular Imaging Core will provide the following services: (1) flow-mediated dilation (FMD) of the brachial artery – a measure of endothelium-dependent vascular reactivity; (2) nitroglycerin-mediated dilation (NTGMD) of the brachial artery – a measure of endothelium-independent vascular reactivity; and (3) carotid intima media thickness (CIMT) – a measure of cumulative arterial injury. By grouping these services within one Core, the interested IUPUI investigator can more directly access one or more of these services and work closely with the Core’s staff in choosing which services are most helpful for their particular research needs.

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Samir K Gupta
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317-274-7926


IIBIS In Vivo Imaging

Affiliation: Indiana Genomics Initiative (INGEN), IU School of Medicine

Director: Gary D. Hutchins, Ph D.

Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Institute for Biomedical Imaging Sciences (IIBIS).

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Mark Holland, PhD
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(317) 274-4307


Imaging and Flow Cytometry Core Facility

Affiliation: Indiana University School of Medicine, South Bend

Core Director: Charles Tessier

The Imaging and Flow Cytometry Core Facility is located at the Indiana University School of Medicine South Bend campus.

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Charles Tessier
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574-631-2519


In Vivo Therapeutics Core

Affiliation: IU Simon Cancer Center

Director: Karen E. Pollok, Ph D.
Manager: Tony Sinn

The IUSCC In Vivo Therapeutics Core (IVT) provides investigators with cost-effective and comprehensive services to facilitate the development and testing of novel pharmacological & cellular therapies. The Core will act as a liaison between the Principal Investigator and any other outcome analyses from live-phase studies. The IVT Core maintains multiple on-site breeding colonies, including: NOD/scid, NOD/scid/IL2Rgnull, Boy/J, F1/BoyJxC57Bl/6 mice, C57BL/6-Tg(UBC-GFP)30Scha/J, and Mgmt -/-

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Tony Sinn
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317-274-8811


Indiana Center for Biological Microscopy (ICBM)

Affiliation: Indiana Genomics Initiative (INGEN), NIH O'Brien National Center for Renal Microscopy, IU Simon Cancer Center, IU School of Medicine

Scientific Director: Kenneth Dunn, Ph D.
Director: Bruce Molitoris, M.D.

High resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis.

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Malgorzata Kamocka
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Indiana CTSI Biospecimen Management Core (CTSL/SSF)

Affiliation: Indiana University School of Medicine

CTSL Director: Christie M. Orschell, Ph.D.
SSF Director: Robert Orr

The Biospecimen Management Core (BMC), comprised of the Specimen Storage Facility and the Clinical and Translational Support Laboratory, offers cost-efficient processing & storage services with a focus on consistent quality and sample integrity.

The Specimen Storage Facility (SSF) currently maintains four mechanical freezer storage sites, a LN2 freezer storage site, and a nucleic acid extraction laboratory. Both investigator and SSF owned freezers are monitored and maintained by SSF staff 24/7 to virtually eliminate specimen loss due to freezer failures. Quality is maintained via our contracted independent QA oversight and guidance. Our facility and procedures are ISBER compliant (International Society for Biological and Environmental Repositories).

The Clinical and Translational Support Laboratory (CTSL) provides SOP-driven, protocol specific processing and shipping services for studies collecting human derived research specimens. The highest levels of quality and consistency are assured due to our voluntary compliance to GCPs and GLPs along with independent QA oversight.



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Robert Orr
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317-944-9726


Indiana University Bloomington Electron Microscopy Center

Affiliation: Indiana University Bloomington

Faculty Director: Dr. Roger Innes
Staff Director: Dr. David Morgan

The Electron Microscopy Center (EMC) provides the IU Bloomington with a state of the art facility for electron microscopy and elemental analysis of materials. The primary focus of the center is to facilitate data acquisition and analysis by campus research personnel. The EMC provides well-maintained equipment, data acquisition services, hands-on training, and fee-for-service by highly trained electron microscopists on staff. Comprising the center is a physical lab space housing a JEOL 3200 intermediate voltage electron microscope and an adjacent space for image processing, both in Simon Hall, together with the JEOL 1010 TEM with associated specimen preparation space in Myers Hall. The center currently has three technical personnel dedicated to materials science and life science.

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Dr. David Morgan
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812.856.1457


Indiana University Cyclotron Operations (IUCO)

Affiliation: IU Bloomington

Director: Dr. Peter Johnstone

The Indiana University Cyclotron Facility (IUCF) is a multidisciplinary laboratory performing research and development in the areas of accelerator physics, nuclear physics, materials science, radiation biophysics, radiation biology and medical applications of accelerators.

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Barbara von Przewoski
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(812) 855-2913


Indiana University Imaging Research Facility (IRF)

Affiliation: IU-Bloomington

MRI physicist: Hu Cheng, Ph D.
Director: Sharlene Newman, Ph D.

The Imaging Research Facility houses a 3 Tesla Siemens TIM Trio MRI scanner with high-fidelity infra-red eye tracking in addition to a high-density (256 channel) EEG/TMS laboratory. The IRF has an additional EEG system that is MRI- and TMS-compatible.

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Sharlene Newman, Ph.D.
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812-856-3723


Infectious Diseases Laboratory

Affiliation: Indiana University School of Medicine

Director: Aaron Ermel, MD

The Infectious Diseases Laboratory (IDL) has provided research support services for multiple investigators as well as clinical diagnostic services for multiple healthcare facilities since 1983. The IDL provides diagnostic services for multiple sexually transmitted pathogens and supports researchers investigating these pathogens as well as behavioral scientists who use acquisition of sexually transmitted pathogens as biologic correlates of sexual behavior. In addition, the IDL has developed its own research agenda participating in research trials of new technologies for the diagnosis of sexually transmitted pathogens, some of which have become standard diagnostic techniques. In addition to the main laboratory, there is an adjacent laboratory under the direction of Dr. Darron Brown that also provides diagnostic services.

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Jim Williams, Lab Manager
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317-274-3248


Investigational Agent Acquisition Program

Affiliation: Indiana University


Goal: The goal of the CTSI Investigational Agent Acquisition Program (IAAP) is to assist CTSI investigators seeking investigational agents for use in clinical trials. Scope: The IAAP program will assist in acquiring drugs, neutraceuticals, biologics or other materials to be used in a Investigational New Drug Application or IND-exempt clinical trial. Eligibility: Any faculty within the CTSI member institutions. Overview: Moving bench research into the clinic has a variety of hurdles. One challenge repeatedly identified by investigators is the acquisition of novel products of interest that are suitable for use in clinical trials. For the most part, investigators have little or no experience in the regulatory requirements for an investigational agent; nor do they have expertise in identifying suitable vendors who can manufacture the required material. The manufacture of some materials, such as neutraceuticals, are generally straightforward and the IAAP can utilize its expertise to generate a roadmap and identify vendors for an investigator to consider. In other cases, for example when suitable active pharmaceutical ingredient (API) is not available, the manufacturing process is highly specialized, the properties of the material are not well characterized, or significant work will be required in defining a manufacturing plan and identifying a suitable production facility, consultants with specific experience must be engaged. The IAPP will meet with investigators, assess their needs and either facilitate the acquisition process or facilitate the hiring of outside consultants skilled in product acquisition. While advice will be provided, ultimately any decisions regarding the manufacturing plan and the acceptability of the material generated lies with the principle investigator. Therefore, users of the IAPP are expected to drive the process, providing requested information in a timely manner and maintain active interactions with consultants and manufacturers.

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Padma Portonovo
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Islet and Physiology Core

Affiliation: IUSM

Director: Dr. Carmella Evans-Molina
Associate Director: Dr. Sarah Tersey

The Islet and Physiology Core of the Indiana Diabetes Research Center provides IUSM and regional (IUB, IUPUI, and Purdue University) investigators with the capability to obtain high quality rodent pancreatic islets for study. The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. We are also pleased to offer several services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition and metabolic cage analysis using TSE System cages. The Islet and Physiology Core functions as part of the Indiana Diabetes Research Center and the IUSM Center for Diabetes and Metabolic Diseases, to foster new knowledge, support training, and promote basic and translational research in diabetes and related metabolic disorders and their complications.

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Sarah Tersey
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(317)278-8940


IU Bloomington Flow Cytometry Core Facility

Affiliation: Indiana University Department of Biology

Manager: Christiane Hassel, MS
Director: Dr. John Foley
Associate Director: Dr. Kris Klueg

The IU Bloomington Flow Cytometry Core Facility (FCCF) offers flow cytometry analysis and cell sorting services. It houses the FACS Aria II, a state-of-the-art sorter/analyzer capable of analyzing fourteen colors and seventeen parameters, the COPAS Select, a Drosophila embryo and large particle sorter, the LSRII, a thirteen-color analyzer with HTS option, the FACSCalibur, a four-color analyzer, as well as Z2 Coulter counter technology used for determining cell concentration and size distribution. Services include technician assisted sorting, as well as training for analyzers and Coulter instruments. Help with experimental design is also available. NEWLY ADDED SUMMER 2017! – Miltenyi MACSQuant VYB mobile flow cytometer – 3 laser, 8 parameter instrument on a cart. Multi-well and absolute counting capabilities.

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Christiane Hassel
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812-855-7101


IUB – Light Microscopy Imaging Center (LMIC)

Affiliation: Indiana University Bloomington

Executive Director: Claire Walczak
Technical Director: Sid Shaw
Facility Manager: Jim Powers

To provide user-friendly access to state of the art light microscopy for the IU research community. To promote the development of researchers that are knowledgeable, confident and comfortable in the use of microscopes.

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IUSCC Tissue Procurement and Distribution Core

Affiliation: IUSCC

Director: Sherif S. Farag
Technical Advisor: George Sandusky
Technical Advisor: Oscar Cummings
Operations Manager: Mary Cox

The broad scientific objective of Indiana University Simon Cancer Center (IUSCC) is to conduct high quality, cutting-edge basic and clinical research for the improved understanding and advancement in the treatment of human malignancies. The ability to successfully investigate the biological basis of cancers, translate basic research to the clinical setting, and better understand the relevance of observed clinical or population-based phenomena through laboratory-based research is greatly facilitated by the availability of an extensive repository of tissue samples, with accompanying pathologic and clinical data, procured from patients with malignancies and normal controls. To serve the needs of the cancer center in achieving this end, the IUSCC Solid Tissue Bank began providing solid tumors in 1996. In 2008, the Hematologic Malignancies Tissue Bank was established to provide hematological malignancies. Since that time, the IUSCC Solid Tissue Bank has continued to provide tissue for the discovery of new drug targets and biomarkers, the development of cancer cell lines and for DNA and RNA research. Over the past 10 years, IUSCC has provided hundreds of tumor samples to many IU leading scientists and affiliates. Specimens with confirmed histology and diagnosis are available from surgery within 90 minutes post excision from a large variety of cancers. Normal adjacent tissue, metastatic tissue, and archival blocks are available. The Hematologic Malignancies Tissue Bank serves as a tissue procurement resource for the centralized banking of blood, bone marrow, leukapheresis, and buccal swab specimens procured from patients with hematologic malignancies and normal controls. All malignant samples are accompanied by clinical and pathological data. Beyond simply serving as a repository of tissue, the IUSCC Tissue Bank is a shared resource of samples that is made available to researchers for the examination of relevant cellular and molecular properties and used in preclinical drug development assays. Please contact us at our email account IN-CANC-TissueBank@exchange.iu.edu with any questions.

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Mary Cox
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317-274-4320


Keck Center for Transgene Research (resources)

Affiliation: University of Notre Dame

Director: Francis J. Castellino, Ph D.

Unique research resources available for collaboration

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Victoria A. Ploplis, Ph.D.
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(574) 631-8996


Laboratory for Biological Mass Spectrometry

Affiliation: Indiana University Bloomington

Director: Jonathan Trinidad

Previous success in proteomics research that has been initially funded by sources such as INGEN, the 21st Century Fund, and the NIH has enabled the emergence of the Proteomics Facility in Simon Hall. This facility has sufficient expertise and instrumentation to serve as an extraordinary asset for life sciences researchers at IUB and beyond.

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Jonathan Trinidad
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812-856-4126


Life Science Microscopy Facility

Affiliation: Purdue University

Director: Chris Gilpin

The LSMF is a full service electron microscopy core with both service and individual use options. Equipment includes field-emission SEMs equipped with cryo, EDX, low vacuum, and tensile stage. Also available are TEMs, routine and cryo sample preparation instrumentation, and other support equipment. Basic light microscopy also available (Bright-field, Nomarski DIC contrast, Fluorescence, stereo).

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Chris Gilpin
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765-494-6666


Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)

Affiliation: Indiana University Bloomington

Executive Director: Charles E. Dann, Ph.D.

The Macromolecular Crystallography Facility at Indiana University, Bloomington welcomes Researchers interested in Structural Biology. Over the past several years there has been a rapid increase on our campus of research into biological structures, spanning from DNA (RNA) protein complexes, viral particles/capids, and protein macromolecules. With this ever growing interest, the MCF provides a home source for X-Ray diffraction data collection from macromolecular crystals and computational support for structure determination and refinement. The Facility houses a Rigaku RUH-3R X-Ray generator with two RaxisIV++ image plate detectors. In addition, we are a member institution in the Molecular Biology Consortium, which allows for easy, remote synchrotron access on beamline 4.2.2 at the Advanced Light Source (ALS), a part of Lawrence Berkeley National Labs in Berkeley, California. This facility was founded to facilitate and encourage research endeavors in structural biology and to provide a centralized resource for training and education in latest crystallographic and structural biology techniques. Furthermore, the facility as a whole proudly introduces the Crystallization Automation Facility (CAF) comprised of three new instruments that provide high throughput robotic automated crystallization. Given the capacity of this syetm, we envision that other research organizations in the region will also benefit from use of the CAF.

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Giovanni Gonzalez-Gutierrez
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812-856-7505


Mass Spectrometry and Proteomics Facility

Affiliation: University of Notre Dame

Director: William Boggess, Ph D.

Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.

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Bill Boggess
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(574) 631-4027


METACyt Biochemical Analysis Center

Affiliation: Indiana University Bloomington

Director: Jonathan A. Karty, Ph D.



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Jonathan A. Karty, Ph D.
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812-856-5620


Molecular Structure Facility

Affiliation: University of Notre Dame

Director: Allen Oliver, Ph D.

The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.

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Allen Oliver, Ph D.
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(574) 631-5935


Multiplex Analysis Core (MAC)

Affiliation: IUSM

Director: Christie M. Orschell, Ph. D

The Multiplex Analysis Core (MAC) offers microplate-based bioassay systems that can perform multiplex analysis of multiple different analytes in a single sample. Multiplex systems are faster, more efficient, and use less sample volume than other technologies such as ELISA and Western Blot. Off-the-shelf kits are available to detect analytes such as chemokines, cytokines, hormones, cell signaling molecules, phosphoproteins, or nucleic acids in areas such as inflammation, metabolism, cardiovascular disease, oncology, immunology, etc. Custom kits designed by the investigator are also a possibility.

The MAC uses a Bio-Plex 200 bead-based suspension system (Luminex platform) for analyte quantitation in the picogram level. Immunoassay kits are available for human, mouse, bovine, canine, porcine, rat, and primate.

The MAC is located at R3-C335 (Walther Hall), 980 W. Walnut St., Indianapolis, IN.

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Hui Lin Chua
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(317)274-3589


Notre Dame Histology Core Facility

Affiliation: University of Notre Dame

Core Director: Bradley Smith, Ph.D.

The Notre Dame Histology Facility (NDHF) provides a means to examine biological processes by use of immunohistochemical techniques and pathology. The facility is equipped with a Leica TP 1020 Tissue Processor, Leica microtome, Tissue-Tek III embedding station, and a Leica Cryostat with a special Tungsten blade attachment capable of slicing un-decalcified bone. The objective of the histology core is to provide high quality stained tissue sections on microscope slides. Services include tissue fixation, processing, embedding, sectioning, and staining of paraffin or frozen tissue sections. Staining of tissue sections ranges from routine H&E’s (Hematoxylin-Eosin) to special stains demonstrating specific tissue structures. The Core offers immunohistochemical staining with antibodies supplied by investigators. Lab Manager: Sarah Chapman, MBA, HT (574) 631-3813 http://ndiif.nd.edu/histology/

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Sarah Chapman
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574-631-3813


Notre Dame Integrated Imaging Facility

Affiliation: University of Notre Dame

Director: Bradley D. Smith, Ph D.

Houses and integrates three areas of imaging expertise. Makes available an integrated suite of sophisticated microscopes and imaging stations that enable the expert users to attack the most complex modern research problems and, equally important, the resident professional staff (technicians and research specialists) to guide the non-expert users and allow them to conduct experiments that were previously beyond their limits.

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Ossabaw Swine Resource

Affiliation: Indiana University School of Medicine, Purdue University

Director: Michael Sturek, Ph.D.
Director: Mouhamad Alloosh, M.D.

The overall goal of the core is to provide Ossabaw miniature swine, technical resources, and tissues for preclinical translational research. Please see also our website for additional description, research articles, etc. We have the only research and large-scale breeding colony of Ossabaw swine in the world that is certified to have a gene mutation, the metabolic syndrome, and heart disease. The striking similarities between swine and human biochemistry, physiology, and pathophysiology provide outstanding opportunities for research in translational medicine. Publications and ongoing projects currently have found 32 uses for Ossabaw miniature swine. Providing this infrastructure and technical and intellectual resource will significantly reduce a limitation for swine research overall.

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Mouhamad Alloosh, M.D.
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317-274-7948


Oxidative Stress and Environmental Analysis Core

Affiliation: Indiana University, Bloomington

Director: Lisa Kamendulis

The Oxidative Stress Environmental Analysis Core laboratory has established a number of measurements for assessing oxidative stress and damage in a variety of biological samples with excellent accuracy and reproducibly using state of the art LC-MSMS, GC, and PCR equipment.

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Lisa Kamendulis
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812-855-3188


Pharmaceutical Manufacturing Core Facility

Affiliation: Purdue University – Department of Industrial and Physical Pharmacy

Director: Daniel T. Smith, Ph D.

Pharmaceutical Manufacturing Core Facility provides support and capabilities for a wide range of research in pharmaceutical development and manufacturing. Technical support for the Facility is provided by the faculty of Industrial and Physical Pharmacy who have extensive pharmaceutical manufacturing experience in both industrial and academic environments.

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765-463-1989 x116


Pre-Clinical Research Laboratory

Affiliation: Purdue University – Center for Comparative Translational Research – College of Veterinary Medicine

Director: Gert Breur, DVM, MS, PhD, DACVS
Manager: Robyn McCain, BS, RLATg

The Pre-Clinical Research Laboratory (PCL) facilitates pre-clinical animal research by providing research expertise, technical support, facilities and equipment. The PCL is a multidisciplinary laboratory where faculty conduct advanced pre-clinical research using induced animal models ranging from rodents to pigs and sheep. Board certified veterinary surgeons associated with the laboratory are available for consultation and collaboration and technical assistance is provided by highly trained veterinary technicians.

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Robyn McCain
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765-496-2504


Preclinical Histology Core (PHC)

Affiliation: ICVBM/Cardiology/Cancer

Assistant Director: Pamela Rogers
Director: George Sandusky

PHC will provide necropsy, histology and pathology support to researchers who use cell lines, xenografts, animal models, and human tissues in their research at various biosafety levels. Individual attention to protocol and technique development,as well as optimizing challenging preclinical scenarios with respect to histology and staining, allows this core to offer individualized services for research and development.\\r\\n\\r\\nPHC provides a researcher with the unique opportunity to design and plan a study which optimizes the best animal model, research protocol, tissue procurement, specimen handling and finally histology. Most errors start with designing a study expecting histology to answer the research objectives. Pre-discussion of histology techniques, specimen preservation details, and supportive blood or fluid samples are all criticial in producing the overall evaluation. Involvement of the PHC in developing the research plan will ultimately decrease errors and improve your research outcomes!

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Pam Rogers
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317.278.0000


Proteomics Core Facility

Affiliation: Indiana Genomics Initiative (INGEN), IU School of Medicine

Director: Amber Mosley, Ph.D.

Identification, quantitation and characterization of proteins, instrumentation development.

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Dr. Amber Mosley
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(317) 278-2350


Purdue Bioinformatics Core

Affiliation: Purdue University Discovery Park

Director: Jyothi Thimmapuram

The vision of the Bioinformatics Core is to facilitate, amplify, and accelerate biological research and discovery through application of bioinformatics. It will do so by delivering high quality analysis in a timely and economical manner. It will be responsive to customer needs and evolve with advances in the field. It will actively engage in and seek out opportunities to advance the educational mission of the University.

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Jyothi Thimmapuram
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765.496.6252


Purdue Bioscience Imaging Facility

Affiliation: Purdue University

Director: Andy Schaber

We provide the instruments and expertise needed to visualize molecules in preparations ranging from single cells to entire animals. For microscopic imaging, the facility houses a Nikon inverted confocal microscope (A1Rsi), a Nikon multi-photon microscope (A1RMP), a Nikon phase/epifluorescence microscope equipped with an EM-CCD (TiS), and a Nikon 90i upright microscope for brightfield color imaging. We are also equipped with a Nikon combination Super Resolution system (both SIM and STORM). Whole animal imaging equipment includes an IVIS Lumina II and the AMI for in vivo optical imaging and the MiLabs VECTor (SPECT/PET/CT). Users receive individualized instrument training as well as project specific advice on data acquisition parameters, post-processing techniques, image rendering, and quantification/analysis.

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Andy Schaber
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765-496-3148


Purdue Bone and Body Composition Core

Affiliation: Purdue University

Director: Connie Weaver, Ph D.
Co-Director: David Burr, Ph D.
Co-Director: Kathleen Hill Gallant, Ph D.

The Bone and Body Composition Core provides services and methods of determining Bone density, bone geometry and body composition in Humans and animals.

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Pamela Lachcik, LATG, MS
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Purdue Cryo-EM Facility

Affiliation: Purdue University

Core Director: Dr. Wen Jiang

The Purdue Cryo-EM Facility is a member of the Purdue EM Consortium and a designated Indiana CTSI Core Facility. Our facility is available to Purdue, other academic institutes, and industry users. It provides state-of-the-art instruments and expertise for high resolution structure determination of viruses, larger macromolecular complexes, nano-particles, as well as tomographic visualization of virus-cell interactions by cryo-electron microscopy (cryo-EM) and three-dimensional (3-D) image reconstruction.

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Wen Jiang, Ph.D.
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(765) 496-8436


Purdue Flow Cytometry and Cell Sorting Facility

Affiliation: Purdue University – Bindley Bioscience Center

Manager: Dr. Jill Hutchcroft

The Flow Cytometry and Cell Separation Facility (FCCSF) provides both state-of-the-art equipment and highly experienced personnel to enable the rapid identification, quantification, and separation of eukaryotic and prokaryotic cells. Flow and image cytometry services are used in the research of life sciences investigators based in a variety of Colleges and Departments.

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Dr. Jill Hutchcroft
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765-586-1130


Purdue Genomics Core Facility

Affiliation: Purdue University

Director: Phillip SanMiguel, Ph.D.

The Purdue Genomics Core accepts DNA or total RNA for construction of DNAseq and several types of RNAseq libraries to be run on an Illumina HiSeq 2500 or Illumina MiSeqs. In addition we offer a novel service, WideSeq, that allows full sequence of double stranded DNA samples up to 100-200kb for $20.

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Phillip San Miguel
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765-496-6328


Purdue Metabolite Profiling Facility

Affiliation: Purdue University – Bindley Bioscience Center

Director: Bruce Cooper

The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative Metabolite (efforts to define or catalog all components of a metabolome) and quantitative Metabolite (understanding differential concentrations of metabolites) for metabolite profiling in biological systems. This facility employs highly sensitive mass spectrometry coupled with multi-dimensional gas and liquid chromatography (GC and LC-MS) to provide researchers with new technologies and methods development, as well as expert training and consultation. This research capability allows assessment of the hierarchical flow of information from the genome to the transcriptome, proteome, and metabolome ultimately defines cellular phenotypes.

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Bruce Cooper
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(765) 494-6282


Purdue MRI Facility

Affiliation: Purdue University

Facilities Director: Dr. Gregory Tamer, Jr.
Faculty Director of Life Sciences MRI Facility: Dr. Ulrike Dydak
Faculty Director of Small Animal MRI Facility: Dr. Craig Goergen
Faculty Director of Engineering MRI Facility: Dr. Tom Talavage

The Purdue MRI Facility now is the union of three MR scanners (and facilities) located directly on the campus of Purdue University. The Small Animal MRI Facility, located in the Bindley Bioscience Center, houses a Bruker Biospec 7T MRI system. The Life Sciences MRI Facility houses a 3T Siemens MAGNETOM Prisma MRI system, and the Engineering MRI Facility houses a GE Discovery MR750 3T MRI system. The latter two share a building and several resources. All three systems are available for research involving magnetic resonance imaging (MRI), MR spectroscopy (MRS), and other MR applications.

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Dr. Gregory Tamer, Jr.
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765-588-7134


Purdue Proteomics Facility

Affiliation: Purdue University – Bindley Bioscience Center

Director: Uma Aryal, Ph.D.

Innovative methodologies and technologies are developed in the Purdue Proteomics Facility (PPF), a shared facility of the Bindley Bioscience Center (BBC) and the Purdue Cancer Center. This facility enables never-before-possible analysis of post-translational modifications of the proteome. Coupled with new proteomics infrastructure and expert scientific researchers, these facilities provide unique approaches to intact protein (‘top-down’) and peptide fragment (‘bottom-up’) analyses. Many projects in Bindley Bioscience Center employ these technologies for biomarker discovery in health and disease – a signature research area at the BBC. Capabilities – Amino acid analysis of peptides or proteins, automated and manual computer search and analyses, bioinformatic consultation, equipment and software for complete 2D gel analyses, ESI analysis of intact proteins, high throughput comparative proteomics with LCMS-MS/MS, identification and characterization of peptide and protein modifications, microscale in-gel tryptic digestion, MALDI MS/MS identification from in-gel digest, MS/MS of purified peptides and proteins, protein identification via database retrieval from nano LC-MS/MS in-gel tryptic digest information, proteomics methods development and consultation, RP-HPLC mapping of peptides from in-gel digests with MS/MS or ESI MS/MS of spectral peaks, targeted analyses of specific molecules with multiple reaction monitoring (MRM) and related techniques with triple quadrupole mass spectrometry.

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Uma Aryal
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(765) 496-4960


Purdue Transgenic Mouse Core Facility

Affiliation:

Director: Stephen Konieczny, Ph. D



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Stephen Konieczny, Ph. D
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Purdue Translational Pharmacology Facility

Affiliation: Bindley Bioscience Center

Director: Greg Knipp
Manager: Robyn McCain



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Email This Core
765.496.6147


Regenstrief Data Core

Affiliation: Regenstrief Institute

Directory: Timothy Imler
Manager, Data Core Services: Faye Smith
Program Manager, Data Core Services: Patricia McGuire
Administrator: Sarah Hoover
Administrator: Anna Roberts

The Regenstrief Institute Data Core, under the leadership of Dr. Timothy Imler MD, MS, provides services and resources through the CTSI Informatics and Data Analysis Core (CIDAC) to assist investigators with research utilizing the Indiana Network for Patient Care (INPC).

Completeness of data varies across each INPC institution and approval to use individual institutions’ data may be required.

The Indiana CTSI and Regenstrief Institute cooperate to provide a limited amount of funding to support the data infrastructure to assist with developing grant proposals, feasibility assessments, and unfunded studies. Remaining Data Core expense is offset by awarded grants, contracts, and other external funding.

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Cindy Majors, Administrative Assistant
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317-274-9153


The Center for Genomics and Bioinformatics

Affiliation: IU Bloomington (College of Arts and Sciences)

Director: Matthew Hahn
Lab Manager: James Ford
Lead Bioinformatician: Doug Rusch

The CGB was created in 2000 by the Office of the Vice Provost for Research (OVPR) and the College of Arts and Sciences at Indiana University. It receives additional support from the School of Informatics and Computing (SOIC), the School of Public Health, the School of Public and Environmental Affairs (SPEA), and IU Medical Sciences. The primary missions of the CGB are to: • Act as a service facility that provides IU faculty access to genome technologies and bioinformatic support. • Provide consulting and training that supports the development of genome-enabled research programs and grant proposals. • Develop new genome technologies and bioinformatics tools that are not easily purchased as a fee for service elsewhere. Our service offerings and policies are viewable at http://cgb.indiana.edu.

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Rock Rockliff
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(812) 855-6877


Therapeutic Validation Core (TVC)

Affiliation: IUSM IUSCC

Director: Ahmad Safa PhD
Associate Director: Chris Stamatkin PhD

The Therapeutic Validation Core (TVC) supports clinical investigators by offering basic science expertise to develop and implement correlative, pharmacodynamic and predictive biomarker assays necessary to validate mechanism(s) of action of novel drugs/therapies and to formulate/test new scientific hypotheses.

The TVC is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.

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Ahmad Safa PhD
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317-278-4952


Transgenic and Knockout Mouse

Affiliation: Indiana Genomics Initiative (INGEN), IU Simon Cancer Center, IU School of Medicine

Director: Loren Field, Ph D.

Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA.

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Hanying Chen
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(317) 278-0163


Translation Core

Affiliation: Indiana University School of Medicine

Director: Kieren Mather, MD
Associate Director: Robert Considine, Ph.D.

The Translation Core provides services that reduce or eliminate barriers to conducting research involving human subjects. Services include metabolic phenotyping (e.g. GTT, clamp studies, tracer studies), measurements of blood analytes (e.g. hormones, cytokines, lipids), maintenance of a biobank of human tissues and serum, and a host of specialized and customizable laboratory services.

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Kieren Mather
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317-278-7826


Translational Genomics Laboratory

Affiliation: IU Simon Cancer Center, IU School of Medicine

Director: Sunil Badve, MD

The Translational Genomics Laboratory provides services for 1) nucleic acid preparation, 2) genotyping, and 3) gene expression profiling.

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Sunil Badve, MD
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(317) 491-6417 (office)(317) 274-5565 (laboratory)


Vector Production Facility

Affiliation: IU School of Medicine

Director: Kenneth Cornetta, MD

Provide retroviral and lentiviral therapy vectors for clinical use and provide reagents and training to investigators seeking research grade reagents. Testing is also available for assistance in clinical gene therapy.

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Ken Cornetta
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(317) 278-195


Veterinary Clinical Trials Support Service

Affiliation: Purdue University – Center for Comparative Translational Research – College of Veterinary Medicine

Director: George E. Moore, DVM, PhD, DACVIM
Trial Coordinator: Becky Bierman, RVT, BS

The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials within the Purdue Veterinary Teaching Hospital and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices. Patients are actively recruited for clinical trials in the ongoing effort to improve both human and animal health and health care.

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Veterinary Clinical Trials
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(765) 496-9715