The Translational Technologies and Resources (TTR) Program will transform research throughout Indiana by moving from a reactive to a proactive group of core support facilities that are highly integrated within the Indiana CTSI. Furthermore, the TTR will transform the research environment at Indiana University (IU) and Purdue University by linking the clinically focused core programs at IU with the outstanding resources available at Purdue, including its renowned veterinary, nanotechnology, and biomedical engineering facilities. The TTR will: 1) actively participate in the CTSI Project Development Teams to help identify projects in which novel technologies can provide added value; 2) facilitate access to novel resources for translational research projects; and 3) provide education to CTSI investigators about novel technologies. Through the integrated TTR Program, we will create a unique statewide resource that can be extended to provide services to other CTSAs around the country.

Research Core Laboratories

• Advanced Information Technology — Bill Barnett, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), IU School of Medicine, University Information Technology Services (UITS) - Research Technologies Division

  Supercomputing, bioinformatics software, massive storage and advanced visualization services

• Bindley Bioscience Center — Richard Kuhn, PhD, Director

  Affiliations: Purdue Discovery Park

  Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.

• Biochemistry Biotechnology Facility — Robert A. Harris, PhD, Director

  Affiliations: IU Simon Cancer Center, IU School of Medicine

  DNA sequencing

• Biostatistics — Barry Katz, PhD, Director

  Affiliations: IU School of Medicine

  Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development.

• Birck Nanotechnology Center — Tim Sands, PhD, Director

  Affiliations: Purdue Discovery Park

  Nanometrology laboratories, complete suite of microelectronics and microfluidics fabrication and testing equipment, bio-pharma clean room.

• Cardiovascular Ischemia and Vasculogenesis (CIVC) — Brian Johnstone, PhD, Director

  Affiliations: Center for Vascular Biology and Medicine, Department of Medicine, IU School of Medicine

  Provides technical expertise and assistance in conducting experiments employing various rodent cardiovascular disease models for generating physiological data or for testing experimental compounds, molecules, cells or devices.

• Cell and Protein Expression — Paresh Sanghani, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), IU School of Medicine, University Information Technology Services (UITS) - Research Technologies Division

  Construction of expression vectors; expression and purification of recombinant proteins

• Center for Medical Genomics — Howard Edenberg, PhD, Director

  Affiliations: Alcohol Research Center, Department of Biochemistry and Molecular Biology, IU School of Medicine

  Experimental design, infrastructure and consulting services for use of array-based technology in studies of disease and other biomedical research.

• Chao Center — Craig W. Davis, PhD, Director

  Affiliations: Purdue Research Park

  Provides non-sterile cGMP manufacturing of clinical trial and small-scale commercial materials, analytical testing, formulation development, and related regulatory documentation.

• Chemical Genomics Core Facility — Zhong-Yin Zhang, PhD, Director

  Affiliations: Department of Biochemistry & Molecular Biology, IU School of Medicine

  Provides investigators with cost-effective access to high throughput screening of structurally-diverse, drug-like small molecules in biological assays to enable investigators to discover small molecule tools for basic research, therapeutic development and diagnostic applications.

• Clinical Pharmacology Analytical Core — David R. Jones, PhD, Director

  Affiliations: Department of Medicine – Clinical Pharmacology Division, IU Simon Cancer Center, IU School of Medicine

  The Analytical Core provides services to 1) assist in the quantification of drugs and/or metabolites, 2) identification of metabolites, and 3) pharmacokinetic analysis of data.

• Computational Biology and Bioinformatics Service Core — Sean Mooney, PhD, Director

  Affiliations: Center for Computational Biology and Bioinformatics, Department of Biochemistry & Molecular Biology, IU School of Medicine

  This core, a service unit of the Center for Computational Biology and Bioinformatics, provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting

• Cytomics — J. Paul Robinson, PhD, Director

  Affiliations: Purdue Discovery Park

  Provides cell measurement systems, development of new cellular detection technologies, and enabling and providing resources for service.

• DEXA Laboratory — Connie Weaver, PhD, Director

  Affiliations: Purdue University

  Collaborative program providing assessment of nutritional, endocrine, and related studies with expertise in the analysis of bone density, bone geometry, and body composition.

• Drosophila Genomic Research Center — Thomas Kaufman, PhD, Director

  Affiliations: Indiana University at Bloomington

  Outstanding resource for comparative genomics, including development of transgenic flies with mutations in candidate human genes.

• Electron Microscopy Center — Vincent Gattone, PhD, Director

  Affiliations: Department of Anatomy & Cell Biology, IU School of Medicine

  This core provides electron microscopy services utilizing either scanning or transmission electron microscopy.

• Flow Cytometry Resource Facility — Edward Srour, PhD, Director

  Affiliations: IU Simon Cancer Center, IU School of Medicine

  Cell sorting, immunofluorescence analysis and other flow cytometric assays.

• In Vivo Imaging — Gary D. Hutchins, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), IU School of Medicine, University Information Technology Services (UITS) - Research Technologies Division

  Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Center of Excellence in Biomedical Imaging.

• Indiana Center for Biological Microscopy — Kenneth Dunn, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), IU Simon Cancer Center, IU School of Medicine

  High resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis.

• IndianaCTSI Biorepository (In Development)

  Affiliations: Indiana CTSI

  The IndianaCTSI Biorepository is being developed to aid researchers in maintaining samples for future analyses. The facility is expected to be completed in spring, 2009. An operations oversight committee is establishing ISBER compliant operating practices.

• Indiana University Cyclotron Facility — James Musser, PhD, Director (Interim)

  Affiliations: IU Bloomington, Office of the Vice-Provost for Research (OVPR)

  Multidisciplinary laboratory performing research and development in the areas of accelerator physics, nuclear physics, materials science, and medical applications for accelerators.

• MDRU Clinical Research Laboratory — John Turek, DVM, PhD, Director

  Affiliations: Purdue University

  Coordinates support of animal clinical trials and analysis (e.g., in pathology, histology, epidemiology, imaging, etc.) for investigators in various academic departments on campus, in Purdue Discovery Park, and in the local private-sector.

• Metabolomics and Proteomics Centers — Juri Adamec, PhD, Director

  Affiliations: Purdue Discovery Park

  Provides both two-dimensional gel and multi-dimensional liquid chromatography separation coupled with mass spectrometer for proteomic analysis. A center for metabolomics provide state-of-the-art technologies, develop new methods, and enable and provide resources for service for both …

• Pharmacogenetics Core — David Flockhart, MD, PhD, Director

  Affiliations: NIH, Department of Medicine, IU School of Medicine

  Assists investigators with identifying relevant gene polymorphisms to test in their study using bioinformatic database searches and drug pharmacology, isolates DNA from subjects on GCRC protocols (DNA/Biochemistry Core Laboratory), and conducts genotyping assays for the specified alleles.

• Purdue MRI Facility — Charles A. Bouman, PhD & Thomas M. Talavage, PhD, Co-Directors

  Affiliations: Purdue University, Weldon School of Biomedical Engineering

  Provides 3T MRI for anatomical and functional imaging of humans and animals in a joint clinical/research setting.

• Proteomics — Mu Wang, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), Alcohol Research Center, INCAPS, IU School of Medicine

  Identification, quantitation and characterization of proteins; instrumentation development.

• Transgenic & Knockout Mouse — Loren Field, PhD, Director

  Affiliations: Indiana Genomics Initiative (INGEN), IU Simon Cancer Center, IU School of Medicine

  Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA.

• Vector Production Facility — Kenneth Cornetta, MD, Director

  Affiliations: IU School of Medicine

  Provides gene therapy vectors at research or clinical grade. It can also provide GMP sterility, endotoxin, and other assays used in certifying products for clinical use.