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GeneGo Now Available:
CTSI and GeneGo have negotiated an agreement to provide access to GeneGo
software tools to all investigators across our Indiana CTSI partner
institutions. This includes both GeneGo's pathway analysis suite MetaCore
and its database searching tool Eureka. Any researcher with an IU, IUPUI,
Purdue or University of Notre Dame e-mail account can:
Do a Eureka search (click search button on the graphic below and, when finished, be sure to click "Logout" on top left. Otherwise you will prevent others from logging in.)
CTSI Designated Core Report/Renewal Form for cores approved in 2009 is available online at http://www.indianactis.org/corerenewal and is due September 1, 2010.
Indiana CTSI TTR Kelley MBA Core Business Planning Project (2010)
The Indiana CTSI TTR Program through a partnership the IU Kelley School of Business MBA program requested proposals for business planning assistance for core facilities. All Indiana CTSI core and resource units were eligible and the RFA noted that priority would be given to proposals will that clearly explain a significant and specific request for business assistance and how such business assistance might be successfully used by other Indiana CTSI Cores or lead to additional successful Indiana CTSI core applications. The Kelley School of Business MBA program provided 3 teams of 3-5 students to serve a 7-8 week engagement on the project as a part of their independent study program for course credit. It was anticipated that core personnel would commit a total of 15-20 hours to the project and that MBA students would contribute approximately 30 hours to the project. The timeline for this project was from late December 2009 with completion late February 2010.
The 3 projects selected and a link to the final projects is provided below:
Clinical Research Center Process Mapping and Gaps Analysis Tool (Diana Spiegel and Laurie Trevino primary contacts.) The deliverables included a Presentation of Project, Condensed Presentation of Project, CRC Process Map, and GCP Gap Analysis Tool.
Indiana CTSI Biorepository Costing and Informatics Model (Ken Cornetta and Lilith Reeves primary contacts.) The deliverables included a Presentation of Project, Costing Model and Costing Model Description.
InVivo Therapeutics Core (Karen Pollok and Tony Sinn primary contacts). The deliverables included a Growth Planning Presentation and Marketing Brochure.
View a comparison of cores offering similar services:
Contact a core or request a service directly:
Denotes a CTSI Designated Core. Investigators who wish to apply for CTSI Core Pilot Grants must apply to a CTSI Core to be eligible to receive these special grants. Learn More
SERVICE CORES
Supercomputing, medical informatics, applications software, massive storage and advanced visualization services, collaboration tools, Indiana CTSI HUB. Learn More William K. Barnett, Ph D. (812) 856-3038
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The AEPCC conducts validated and highly reproducible in vitro and in vivo assays systems in endothelial and hematopoietic progenitor cell biology. Learn More Jamie Case, Ph D. (317) 278-8249
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Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials. Learn More
Provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting. Learn More Dr. Lang Li
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Provides consulting, access, and assistance for common genomics/bioinformatics analyses. Most of our current consulting portfolio centers on data produced by our sister Genomics core. Learn More Scott Emrich, Ph D. (574) 631-0353
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Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development. Learn More (317) 274-2661
Nanometrology laboratories, complete suite of microelectronics and microfuidics fabrication and testing equipment, bio-pharma clean room. Learn More Monica Allain, Ph D.
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Provides technical expertise and assistance in conducting experiments employing various rodent cardiovascular disease models for generating physiological data for testing experimental compounds, molecules, cells or devices. Learn More Brian Johnstone, Ph D. (317) 278-6107
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Experimental design, infrastructure and consulting services for use of array-based technology in studies of disease and other biomedical research. Learn More Howard J. Edenberg, Ph D.
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Molecular structure and dynamics determination from a wide variety of compounds. Learn More Jaroslav Zajicek, Ph D. (574) 631-9111
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3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery. Learn More David Hyde, Ph D. (574) 631-8054
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Provides investigators with cost-effective access to high throughput screening of structurally-diverse, drug-like small molecules in biological assays to enable investigators to discover small molecule tools for basic research, therapeutic development and diagnostic applications. Learn More Email This Core
The purpose of the Clinical Discovery Laboratory (CDL) is to facilitate pre-clinical animal research by providing research expertise, technical support, facilities and equipment. The CDL is a multidisciplinary laboratory where faculty conduct advanced clinical and applied research using induced animal models. Board certified veterinary surgeons associated with the laboratory are available for consultation and collaboration and technical assistance is provided by highly trained veterinary technicians. Learn More Lee Ann Grote 765-496-2504
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Provides services to 1) assist in the quantification of drugs and/or metabolites, 2) identification of metabolites, and 3) pharmacokinetic analysis of data. Learn More David Jones, Ph D. (317) 630-8726
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The Clinical Trials Group (CTG) is part of the School of Veterinary Medicine’s Medical Discovery Resource Unit. The Clinical Trials Group facilitates animal clinical trials within the Purdue Veterinary Teaching Hospital and provides expertise and technical support for translational clinical investigations using spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices for use in companion and food animals.
Patients are actively recruited for clinical trial research in the ongoing effort to improve the care and treatment of all animals, large and small. Learn More (765) 496-9715
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Resource for comparative genomics, including development of transgenic flies with mutations in candidate human genes. Learn More
Provides electron microscopy services utilizing either scanning or transmission electron microscopy. Learn More Vincent H. Gattone II, Ph D. (31) 274-2505
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Cell sorting, immunoflourescence analysis and other flow cytometric assays. Learn More Edward Srour, Ph D. (317) 274-3589
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Range of sequencing and expression analysis. The Genomics Core has an ABI 3730, Roche 454 Genome Sequencer, Affymetrix GeneChip Workstation, NimbleGen Hybridization system, GenePix scanner, and TaqMan technology. Learn More John Tan, PhD (574) 631-1902
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Performs GLP mouse efficacy studies for radiomitigators. Learn More Christie M. Orschell
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Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Institute for Biomedical Imaging Sciences (IIBIS). Learn More Wendy L. Winkle (317) 278-3167
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High resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis. Learn More Jeff Clendenon
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ISBER Best Practices compliant, SOP driven, electronic access controlled, and remote alarm monitored storage space with available back-up storage units in the event of equipment failure. We have capacity for 60 mechanical freezers and 300,000 specimens stored in vapor phase liquid nitrogen and provide LN2 unit fill service. We offer specimen processing support for your IRB approved protocol and sample and management via the CaTissue sample and protocol management system. We collaborate with IRB approved biorepository processes to connect investigators with specimen sources. Learn More Lilith Reeves, MS, MT(ASCP)SH (317) 278-6930
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The Indiana University Cyclotron Facility (IUCF) is a multidisciplinary laboratory performing research and development in the areas of accelerator physics, nuclear physics, materials science, radiation biophysics, radiation biology and medical applications of accelerators. Learn More Susan Klein, Ph D. (812) 855-9365
Unique research resources available for collaboration Learn More Rashna Balsara (574) 631-2958
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The LSMF is a full service electron microscopy core with both service and individual use options. Equipment includes field-emission SEMs equipped with cryo, EDX, low vacuum, and tensile stage. Also available are TEMs, routine and cryo sample preparation instrumentation, and other support equipment. Learn More Debby Sherman 765-494-6666
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Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics. Learn More Bill Boggess (574) 631-4027
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Houses and integrates three areas of imaging expertise. Makes available an integrated suite of sophisticated microscopes and imaging stations that enable the expert users to attack the most complex modern research problems and, equally important, the resident professional staff (technicians and research specialists) to guide the non-expert users and allow them to conduct experiments that were previously beyond their limits. Learn More
The overall goal of the core is to provide Ossabaw miniature swine, technical resources, and tissues for preclinical translational research. Please see also our website for additional description, research articles, etc. We have the only research and large-scale breeding colony of Ossabaw swine in the world that is certified to have a gene mutation, the metabolic syndrome, and heart disease. The striking similarities between swine and human biochemistry, physiology, and pathophysiology provide outstanding opportunities for research in translational medicine. Publications and ongoing projects currently have found 32 uses for Ossabaw miniature swine. Providing this infrastructure and technical and intellectual resource will significantly reduce a limitation for swine research overall. Learn More Mouhamad Alloosh, M.D. 317-278-3711
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Pharmaceutical Manufacturing Core Facility provides support and capabilities for a wide range of research in pharmaceutical development and manufacturing. Technical support for the Facility is provided by the faculty of Industrial and Physical Pharmacy who have extensive pharmaceutical manufacturing experience in both industrial and academic environments. Learn More 765-463-1989 x116
PHC will provide necropsy, histology and pathology support to researchers who use cell lines, xenografts, animal models, and human tissues in their research at various biosafety levels. Individual attention to protocol and technique development,as well as optimizing challenging preclinical scenarios with respect to histology and staining, allows this core to offer individualized services for research and development.\r\n\r\nPHC provides a researcher with the unique opportunity to design and plan a study which optimizes the best animal model, research protocol, tissue procurement, specimen handling and finally histology. Most errors start with designing a study expecting histology to answer the research objectives. Pre-discussion of histology techniques, specimen preservation details, and supportive blood or fluid samples are all criticial in producing the overall evaluation. Involvement of the PHC in developing the research plan will ultimately decrease errors and improve your research outcomes! Learn More Pam Rogers 317.278.0000
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Identification, quantitation and characterization of proteins, instrumentation development. Learn More Dr. Mu Wang (317) 278-1446
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Construction of expression vectors, expression and purification of recombinant proteins. Learn More Tom Hurley, Ph D. (317) 278-2008
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Collaborative program providing assessment of nutritional, endocrine, and related studies with expertise in the analysis of bone density, bone geometry, and body composition. Learn More Connie Weaver, Ph D.
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The Flow Cytometry and Cell Separation Facility (FCCSF) provides both state-of-the-art equipment and highly experienced personnel to enable the rapid identification, quantification, and separation of eukaryotic and prokaryotic cells. Flow and image cytometry services are used in the research of life sciences investigators based in a variety of Colleges and Departments. Learn More Justin Meyers 765-494-3505
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Purdue University, through the School of Veterinary Medicine, offers histology expertise for investigators involved in biomedical research through the Purdue Histology & Phenotyping Laboratory (PHPL). The PHPL is comprised of two units. One unit is a full service histology laboratory that not only provides routine procedures, but also functions to collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). The other unit is a state of the art bone and articulation laboratory that provides decalcified and non-decalcified techniques, and prosthesis sectioning. This unit also functions to collaborate with investigators in the development of new techniques for biomaterials with application to biomedical research. The PHPL is directed by Dr. Paul W. Snyder who oversees the units and provides expertise in the development, validation and interpretation of the studies performed in these laboratories. Expertise in the processing and histological assessment of bones and joints is provided by Dr. David Van Sickle, Professor Emeritus, Purdue University. Learn More Paul Snyder (765) 494-9676
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The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative Metabolite (efforts to define or catalog all components of a metabolome) and quantitative Metabolite (understanding differential concentrations of metabolites) for metabolite profiling in biological systems. This facility employs highly sensitive mass spectrometry coupled with multi-dimensional gas and liquid chromatography (GC and LC-MS) to provide researchers with new technologies and methods development, as well as expert training and consultation. This research capability allows assessment of the hierarchical flow of information from the genome to the transcriptome, proteome, and metabolome ultimately defines cellular phenotypes. Learn More Bruce Cooper (765) 494-6282
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Provides 3T MRI for anatomical and functional imaging of humans and animals in a joint clinical/research setting. Learn More Email This Core
Innovative methodologies and technologies are developed in the Purdue Proteomics Facility (PPF), a shared facility of the Bindley Bioscience Center (BBC) and the Purdue Cancer Center. This facility enables never-before-possible analysis of post-translational modifications of the proteome. Coupled with new proteomics infrastructure and expert scientific researchers, these facilities provide unique approaches to intact protein (‘top-down’) and peptide fragment (‘bottom-up’) analyses. Many projects in Bindley Bioscience Center employ these technologies for biomarker discovery in health and disease – a signature research area at the BBC.
Capabilities - Amino acid analysis of peptides or proteins, automated and manual computer search and analyses, bioinformatic consultation, equipment and software for complete 2D gel analyses, ESI analysis of intact proteins, high throughput comparative proteomics with LCMS-MS/MS, identification and characterization of peptide and protein modifications, microscale in-gel tryptic digestion, MALDI MS/MS identification from in-gel digest, MS/MS of purified peptides and proteins, protein identification via database retrieval from nano LC-MS/MS in-gel tryptic digest information, proteomics methods development and consultation, RP-HPLC mapping of peptides from in-gel digests with MS/MS or ESI MS/MS of spectral peaks, targeted analyses of specific molecules with multiple reaction monitoring (MRM) and related techniques with triple quadrupole mass spectrometry. Learn More Dorota Inerowicz, Ph.D. (765) 494-6540
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The Center for Genomics and Bioinformatics is a multidisciplinary research center serving primarily the Indiana University Bloomington campus. The CGB carries out independent research in genomics and bioinformatics, collaborates with and/or assists projects developed by IUB faculty, and promotes interdepartmental and interdisciplinary interactions to enhance genomics and bioinformatics at IUB. Our interactions have grown to include faculty at IUSOM, IUPUI, Purdue, and elsewhere around the world. Learn More Jennifer Stenbachs
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30,000 sq. ft. state-of-the-art animal research facility. Fully accredited with highly trained, certified, professional staff. Learn More Mark Suckow, DVM (574) 631-6085
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Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA. Learn More William Carter (317) 278-0163
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The Translational Genomics Laboratory provides services for 1) nucleic acid preparation, 2) genotyping, and 3) gene expression profiling. Learn More Sunil Badve, MD (317) 491-6417 (office)(317) 274-5565 (laboratory)
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Provides gene therapy vectors at research or clinical grade. Can also provide GMP, endotoxin, and other assays used in certifying products for clinical use. Learn More Scott Cross (317) 278-1628
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The Veterinary School Laboratory Animal Care (VLAC) facility facilitates the design of relevant and valid scientific experiments using animal models to ensure protocol designs that are appropriate for institutional guidelines, USDA compliance and AALAC accreditation. The support staff are veterinary technologists or highly trained laboratory animal care personnel. Specialized equipment in this core is primarily connected with the housing and husbandry needs of the animals. For examples, VLAC has housing for upwards of 30,000 rodents in ventilated racks. The users of this facility are anyone involved in animal experimentation as well as numerous users from the pharmaceutical and biomedical device industry. Learn More Jerry K. Davis, Ph D. 765-494-1234
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X-ray structural studies of small molecules (ca. 2kDa) Learn More Allen Oliver, Ph D. (574) 631-5935
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Denotes a CTSI Designated Core. Investigators who wish to apply for CTSI Core Pilot Grants must apply to a CTSI Core to be eligible to receive these special grants.