Denotes a CTSI Designated Core.
Investigators who wish to apply for CTSI Core Pilot Grants must apply to a CTSI Core to be eligible to receive these special grants. Learn More
Supercomputing, medical informatics, applications software, massive storage and advanced visualization services, collaboration tools, Indiana CTSI HUB. Learn More William K. Barnett, Ph D. (812) 856-3038
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The AEPCC conducts validated and highly reproducible in vitro and in vivo assays systems in endothelial and hematopoietic progenitor cell biology. Learn More Jamie Case, Ph D. (317) 278-8249
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Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials. Learn More
Provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting. Learn More Dr. Lang Li
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The purpose of the BioAnalytical Lab at the Bindley Biosciences Center is to initiate long term productive collaborations and to provide a complete biophysical analysis of your sample. In the lab there are two analytical ultracentrifuges: Beckman-Coulter XLI and XLA, and a Biacore 3000 . With these instruments we can determine kinetic parameters, stoichiometry of binding, size distribution, shape, oligomerization state and other biophysical measurements. Complementing these traditional biophysical methods, the BioAnalytical Lab also provides mass spectrometric analyses at both the protein and peptide levels. Learn More Lake Paul 765.494.4960
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Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development. Learn More (317) 274-2661
Nanometrology laboratories, complete suite of microelectronics and microfuidics fabrication and testing equipment, bio-pharma clean room. Learn More Monica Allain, Ph D.
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Provides technical expertise and assistance in conducting experiments employing various rodent cardiovascular disease models for generating physiological data for testing experimental compounds, molecules, cells or devices. Learn More Brian Johnstone, Ph D. (317) 278-6107
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CEEP, Indiana\'s leading program evaluation and education policy research center, promotes and supports rigorous program evaluation and education policy research for educational, human services, and nonprofit organizations. CEEP is interested in working with programs that promise real impact and improvement in education, the lives of children, and communities. Clients include federal and state agencies, public and private organizations, and foundations and endowments primarily working in the fields of public health, education, and youth development. Learn More Jonathan A. Plucker, Ph.D. 800-511-6575
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Experimental design, infrastructure and consulting services for use of array-based technology in studies of disease and other biomedical research. Learn More Howard J. Edenberg, Ph D.
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Molecular structure and dynamics determination from a wide variety of compounds. Learn More Jaroslav Zajicek, Ph D. (574) 631-9111
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3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery. Learn More David Hyde, Ph D. (574) 631-8054
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Provides investigators with cost-effective access to high throughput screening of structurally-diverse, drug-like small molecules in biological assays to enable investigators to discover small molecule tools for basic research, therapeutic development and diagnostic applications. Learn More Email This Core
The purpose of the Clinical Discovery Laboratory (CDL) is to facilitate pre-clinical animal research by providing research expertise, technical support, facilities and equipment. The CDL is a multidisciplinary laboratory where faculty conduct advanced clinical and applied research using induced animal models. Board certified veterinary surgeons associated with the laboratory are available for consultation and collaboration and technical assistance is provided by highly trained veterinary technicians. Learn More Lee Ann Grote 765-496-2504
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Provides services to 1) assist in the quantification of drugs and/or metabolites, 2) identification of metabolites, and 3) pharmacokinetic analysis of data. Learn More David Jones, Ph D. (317) 630-8726
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The Clinical Trials Group (CTG) is part of the School of Veterinary Medicine’s Medical Discovery Resource Unit. The Clinical Trials Group facilitates animal clinical trials within the Purdue Veterinary Teaching Hospital and provides expertise and technical support for translational clinical investigations using spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices for use in companion and food animals.
Patients are actively recruited for clinical trial research in the ongoing effort to improve the care and treatment of all animals, large and small. Learn More (765) 496-9715
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Resource for comparative genomics, including development of transgenic flies with mutations in candidate human genes. Learn More
Provides electron microscopy services utilizing either scanning or transmission electron microscopy. Learn More Vincent H. Gattone II, Ph D. (31) 274-2505
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Cell sorting, immunoflourescence analysis and other flow cytometric assays. Learn More Edward Srour, Ph D. (317) 274-3589
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We provide sequencing and microarray services including consulting for appropriate experimental design, use of technology, and data analysis. The scientific equipment available in this facility include an Applied Biosystems 3730xl automated capillary sequencer, Agilent 2100 Bioanalyzer, Ambion flashPAGE Fractionator System, Affymetrix GeneChip System, Roche NimbleGen MS 200 scanner, and Roche 454 Genome Sequencer FLX pyrosequencer. Our computing facilities are equipped with high performance hardware, a collection of software packages and in-house pipelines, and a team of trained bioinformaticians who are dedicated to analyzing large-scale data sets including data from genomic, metagenomic, gene expression, and proteomic projects. Learn More Mike Pfrender, Ph.D. (574) 631-0591
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Performs GLP mouse efficacy studies for radiomitigators. Learn More Christie M. Orschell
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Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Institute for Biomedical Imaging Sciences (IIBIS). Learn More Wendy L. Winkle (317) 278-3167
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The Imaging and Flow Cytometry Core Facility is located at the Indiana University School of Medicine South Bend campus. Learn More Charles Tessier 574-631-2519
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The IUSCC In Vivo Therapeutics Core (IVT) provides investigators with cost-effective and comprehensive services to facilitate the development and testing of novel pharmacological & cellular therapies.
The Core will act as a liaison between the Principal Investigator and any other outcome analyses from live-phase studies. The IVT Core maintains multiple on-site breeding colonies, including: NOD/scid, NOD/scid/IL2Rgnull, Boy/J, F1/BoyJxC57Bl/6 mice, C57BL/6-Tg(UBC-GFP)30Scha/J, and Mgmt -/- Learn More Tony Sinn 317-274-8811
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High resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis. Learn More Jeff Clendenon
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ISBER Best Practices compliant, SOP driven, electronic access controlled, and remote alarm monitored storage space with available back-up storage units in the event of equipment failure. We have capacity for 60 mechanical freezers and 300,000 specimens stored in vapor phase liquid nitrogen and provide LN2 unit fill service. We offer specimen processing support for your IRB approved protocol and sample and management via the CaTissue sample and protocol management system. We collaborate with IRB approved biorepository processes to connect investigators with specimen sources. Learn More Lilith Reeves, MS, MT(ASCP)SH (317) 278-6930
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The Indiana University Cyclotron Facility (IUCF) is a multidisciplinary laboratory performing research and development in the areas of accelerator physics, nuclear physics, materials science, radiation biophysics, radiation biology and medical applications of accelerators. Learn More Barbara von Przewoski (812) 855-2913
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Previous success in proteomics research that has been initially funded by sources such as INGEN, the 21st Century Fund, and the NIH has enabled the emergence of the Proteomics Facility in Simon Hall. This facility has sufficient expertise and instrumentation to serve as an extraordinary asset for life sciences researchers at IUB and beyond. Learn More Randy J. Arnold 812-856-0208
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The Investigational Drug and Biologics Core is a collaborative project to identify resources and guide the manufacturing process for investigator driven drug/compound or biologics clinical trials. The National Institute for Pharmaceutical Technology and Education (NIPTE) along with the Investigational Drug Services (IDS) and CTSI TTR and Regulatory Programs work closely with the investigator to resolve issues related to formulation, synthesis, manufacturing and regulatory hurdles in the most cost efficient manner possible. A request may be submitted using the order form link below. Learn More Lilith Reeves
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To provide user-friendly access to state of the art light microscopy for the IU research community. To promote the development of researchers that are knowledgeable, confident and comfortable in the use of microscopes. Learn More
The broad scientific objective of Indiana University Simon Cancer Center (IUSCC) is to conduct high quality, cutting-edge basic and clinical research for the improved understanding and advancement in the treatment of human malignancies. The ability to successfully investigate the biological basis of cancers, translate basic research to the clinical setting, and better understand the relevance of observed clinical or population-based phenomena through laboratory-based research is greatly facilitated by the availability of an extensive repository of tissue samples, with accompanying pathologic and clinical data, procured from patients with malignancies and normal controls.
To serve the needs of the cancer center in achieving this end, the IUSCC Solid Tissue Bank began providing solid tumors in 1996. In 2008, the Hematologic Malignancies Tissue Bank was established to provide hematological malignancies.
Since that time, the IUSCC Solid Tissue Bank has continued to provide tissue for the discovery of new drug targets and biomarkers, the development of cancer cell lines and for DNA and RNA research. Over the past 10 years, IUSCC has provided hundreds of tumor samples to many IU leading scientists and affiliates.
Specimens with confirmed histology and diagnosis are available from surgery within 90 minutes post excision from a large variety of cancers. Normal adjacent tissue, metastatic tissue, and archival blocks are available.
The Hematologic Malignancies Tissue Bank serves as a tissue procurement resource for the centralized banking of blood, bone marrow, leukapheresis, and buccal swab specimens procured from patients with hematologic malignancies and normal controls. All malignant samples are accompanied by clinical and pathological data.
Beyond simply serving as a repository of tissue, the IUSCC Tissue Bank is a shared resource of samples that is made available to researchers for the examination of relevant cellular and molecular properties and used in preclinical drug development assays.
Please contact us at our email account IN-CANC-TissueBank@exchange.iu.edu with any questions. Learn More Colleen Mitchell 317-278-9016
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Unique research resources available for collaboration Learn More Rashna Balsara, Ph.D. (574) 631-2958
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The LSMF is a full service electron microscopy core with both service and individual use options. Equipment includes field-emission SEMs equipped with cryo, EDX, low vacuum, and tensile stage. Also available are TEMs, routine and cryo sample preparation instrumentation, and other support equipment. Basic light microscopy also available (Bright-field, Nomarski DIC contrast, Fluorescence, stereo). Learn More Debby Sherman 765-494-6666
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Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics. Learn More Bill Boggess (574) 631-4027
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The School of Veterinary Medicine\'s Medical Discovery Resource Unit (MDRU) mission is to support campus-wide interdisciplinary research by providing the professional expertise (histology, pathology, imaging, investigative surgery, etc.) and facilities needed to support preclinical & translational biomedical investigation. It provides collaborative support for investigators in various academic departments on campus, in Discovery Park, and in the local private-sector. It provides opportunities for hands-on learning and training of graduate, undergraduate and professional students with an interest in comparative biomedical research. Learn More
The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques. Learn More Allen Oliver, Ph D. (574) 631-5935
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Houses and integrates three areas of imaging expertise. Makes available an integrated suite of sophisticated microscopes and imaging stations that enable the expert users to attack the most complex modern research problems and, equally important, the resident professional staff (technicians and research specialists) to guide the non-expert users and allow them to conduct experiments that were previously beyond their limits. Learn More
The overall goal of the core is to provide Ossabaw miniature swine, technical resources, and tissues for preclinical translational research. Please see also our website for additional description, research articles, etc. We have the only research and large-scale breeding colony of Ossabaw swine in the world that is certified to have a gene mutation, the metabolic syndrome, and heart disease. The striking similarities between swine and human biochemistry, physiology, and pathophysiology provide outstanding opportunities for research in translational medicine. Publications and ongoing projects currently have found 32 uses for Ossabaw miniature swine. Providing this infrastructure and technical and intellectual resource will significantly reduce a limitation for swine research overall. Learn More Mouhamad Alloosh, M.D. 317-278-3711
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The Oxidative Stress Environmental Analysis Core laboratory has established a number of measurements for assessing oxidative stress and damage in a variety of biological samples with excellent accuracy and reproducibly using state of the art LC-MSMS, GC, and PCR equipment. Learn More Lisa Kamendulis 812-855-3188
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Pharmaceutical Manufacturing Core Facility provides support and capabilities for a wide range of research in pharmaceutical development and manufacturing. Technical support for the Facility is provided by the faculty of Industrial and Physical Pharmacy who have extensive pharmaceutical manufacturing experience in both industrial and academic environments. Learn More 765-463-1989 x116
This facility enables researchers to identify and quantify proteins in simple or complex samples and characterize protein post-translational modifications or conjugates. Combining a new mass spectrometry-based analytical platform, IdentiQuantXL™, large format/high throughput gel-based proteomics, and experienced proteomic researchers, the PPCF provides unique approaches to biomarker discovery in health and disease, equipment and software for 1D or 2D gel analyses, Western blotting, high throughput differential expression proteomics with LC-MS/MS, identification/characterization of peptide and protein modifications, MS/MS of purified peptides and proteins, protein identification via LC-MS/MS of gel-plug or solution tryptic digests, targeted analyses of specific molecules with selected reaction monitoring (SRM), and proteomics methods development, consultation, and bioinformatic analysis of complicated results. Learn More Frank A. Witzmann, Ph.D. 317-278-5741
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PHC will provide necropsy, histology and pathology support to researchers who use cell lines, xenografts, animal models, and human tissues in their research at various biosafety levels. Individual attention to protocol and technique development,as well as optimizing challenging preclinical scenarios with respect to histology and staining, allows this core to offer individualized services for research and development.\r\n\r\nPHC provides a researcher with the unique opportunity to design and plan a study which optimizes the best animal model, research protocol, tissue procurement, specimen handling and finally histology. Most errors start with designing a study expecting histology to answer the research objectives. Pre-discussion of histology techniques, specimen preservation details, and supportive blood or fluid samples are all criticial in producing the overall evaluation. Involvement of the PHC in developing the research plan will ultimately decrease errors and improve your research outcomes! Learn More Pam Rogers 317.278.0000
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Identification, quantitation and characterization of proteins, instrumentation development. Learn More Dr. Mu Wang (317) 278-0296
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Construction of expression vectors, expression and purification of recombinant proteins. Learn More Tom Hurley, Ph D. (317) 278-2008
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We provide the instruments and expertise needed to visualize molecules in preparations ranging from single cells to entire animals. For microscopic imaging, the facility houses two Nikon confocal microscopes (inverted A1R, upright C1+), a Nikon multi-photon microscope (A1R_MP), a Nikon phase/epifluorescence wide-field microscope (Ti-S) equipped with an EM-CCD or color camera, and a Nikon stereoscope (SMZ1000). Whole animal imaging equipment includes an IVIS Lumina II for in vivo optical imaging and an MiLabs combined microSPECT / microCT with 0.35 mm3 SPECT resolution.
Users receive individualized instrument training as well as project specific advice on data acquisition parameters, post-processing techniques, image rendering, and quantification/analysis. Learn More Aaron Taylor 765-496-3148
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Collaborative program providing assessment of nutritional, endocrine, and related studies with expertise in the analysis of bone density, bone geometry, and body composition. Learn More Connie Weaver, Ph D.
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The Flow Cytometry and Cell Separation Facility (FCCSF) provides both state-of-the-art equipment and highly experienced personnel to enable the rapid identification, quantification, and separation of eukaryotic and prokaryotic cells. Flow and image cytometry services are used in the research of life sciences investigators based in a variety of Colleges and Departments. Learn More Justin Meyers 765-494-3505
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Purdue University, through the School of Veterinary Medicine, offers histology expertise for investigators involved in biomedical research through the Purdue Histology & Phenotyping Laboratory (PHPL). The PHPL is comprised of two units. One unit is a full service histology laboratory that not only provides routine procedures, but also functions to collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). The other unit is a state of the art bone and articulation laboratory that provides decalcified and non-decalcified techniques, and prosthesis sectioning. This unit also functions to collaborate with investigators in the development of new techniques for biomaterials with application to biomedical research. The PHPL is directed by Dr. Paul W. Snyder who oversees the units and provides expertise in the development, validation and interpretation of the studies performed in these laboratories. Expertise in the processing and histological assessment of bones and joints is provided by Dr. David Van Sickle, Professor Emeritus, Purdue University. Learn More Paul Snyder (765) 494-9676
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The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative Metabolite (efforts to define or catalog all components of a metabolome) and quantitative Metabolite (understanding differential concentrations of metabolites) for metabolite profiling in biological systems. This facility employs highly sensitive mass spectrometry coupled with multi-dimensional gas and liquid chromatography (GC and LC-MS) to provide researchers with new technologies and methods development, as well as expert training and consultation. This research capability allows assessment of the hierarchical flow of information from the genome to the transcriptome, proteome, and metabolome ultimately defines cellular phenotypes. Learn More Bruce Cooper (765) 494-6282
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Provides 3T MRI for anatomical and functional imaging of humans and animals in a joint clinical/research setting. Learn More Email This Core
Innovative methodologies and technologies are developed in the Purdue Proteomics Facility (PPF), a shared facility of the Bindley Bioscience Center (BBC) and the Purdue Cancer Center. This facility enables never-before-possible analysis of post-translational modifications of the proteome. Coupled with new proteomics infrastructure and expert scientific researchers, these facilities provide unique approaches to intact protein (‘top-down’) and peptide fragment (‘bottom-up’) analyses. Many projects in Bindley Bioscience Center employ these technologies for biomarker discovery in health and disease – a signature research area at the BBC.
Capabilities - Amino acid analysis of peptides or proteins, automated and manual computer search and analyses, bioinformatic consultation, equipment and software for complete 2D gel analyses, ESI analysis of intact proteins, high throughput comparative proteomics with LCMS-MS/MS, identification and characterization of peptide and protein modifications, microscale in-gel tryptic digestion, MALDI MS/MS identification from in-gel digest, MS/MS of purified peptides and proteins, protein identification via database retrieval from nano LC-MS/MS in-gel tryptic digest information, proteomics methods development and consultation, RP-HPLC mapping of peptides from in-gel digests with MS/MS or ESI MS/MS of spectral peaks, targeted analyses of specific molecules with multiple reaction monitoring (MRM) and related techniques with triple quadrupole mass spectrometry. Learn More Dorota Inerowicz, Ph.D. (765) 494-6540
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Our mission is to enhance discovery, facilitate the inclusion of cell biology in all life science research, and make it possible for all Purdue researchers to have access to the highest quality imaging technology at reasonable cost. Based on investigator identified needs, microfluidics, liquid crystals and other crystal structures, among other non-biological samples are imaged in the facility. Investigators have access to state of the art equipment: the Zeiss LSM 710 confocal spectral scanning microscope and workstation for data processing, Nikon Eclipse E800 epifluorescence microscope equipped with DIC, and Intavis preparative robot for immunolocalizations and in situ hybridization of whole mounts and sections.
Specialized equipment:
(1) Zeiss LSM 710 confocal spectral scanning microscope and workstation for data processing. This is the only spectral scanning microscope on campus
(2) Nikon Eclipse E800 epifluorescence microscope equipped with DIC
(3) Intavis preparative robot for immunolocalizations and in situ hybridization of whole mounts and sections.
Distinctive expertise of personnel:
(1) Angus Murphy, professor, imaging non-biological samples and computer software
(2) Wendy Peer, assistant professor, expert imaging biological sample, small molecule imaging, new method development
(3) Greg Richter, post-doctoral fellow, expert in imaging biological and non-biological samples, new method development. Dr. Richter is responsible for basic training and routine activities. Learn More Wendy Peer, Ph. D 765-496-4955
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The synthesis core facility is a research and service center established to accelerate research activities in all areas of studies on the molecular level in chemistry, biochemistry, biology, medicine, and engineering. The facility includes both teaching and service components. The facility houses several instruments and provides professional staff services that are available to customers based upon a fee structure to recover costs. Synthesis core facility customers may be trained to use most of the instruments. Trained individuals will have unsupervised access to the instruments. The facility also provides assisted use of the instruments. Learn More Viktor Krchnak 574-631-5113
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The Center for Genomics and Bioinformatics is a multidisciplinary research center serving primarily the Indiana University Bloomington campus. The CGB carries out independent research in genomics and bioinformatics, collaborates with and/or assists projects developed by IUB faculty, and promotes interdepartmental and interdisciplinary interactions to enhance genomics and bioinformatics at IUB. Our interactions have grown to include faculty at IUSOM, IUPUI, Purdue, and elsewhere around the world.\r\n\r\nOur service offerings and policies are viewable at http://cgb.indiana.edu/services/ Learn More Jennifer Steinbachs
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30,000 sq. ft. state-of-the-art animal research facility. Fully accredited with highly trained, certified, professional staff. Learn More Mark Suckow, DVM (574) 631-6085
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‘The Therapeutic Validation Core (TVC) supports clinical investigators by offering basic science expertise to develop and implement correlative, pharmacodynamic and predictive biomarker assays necessary to validate mechanism(s) of action of novel drugs/therapies and to formulate/test new scientific hypotheses. Learn More Nagendra K. Prasad
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Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA. Learn More William Carter (317) 278-0163
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The Translational Genomics Laboratory provides services for 1) nucleic acid preparation, 2) genotyping, and 3) gene expression profiling. Learn More Sunil Badve, MD (317) 491-6417 (office)(317) 274-5565 (laboratory)
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Provides gene therapy vectors at research or clinical grade. Can also provide GMP, endotoxin, and other assays used in certifying products for clinical use. Learn More Scott Cross (317) 278-1628
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The Veterinary School Laboratory Animal Care (VLAC) facility facilitates the design of relevant and valid scientific experiments using animal models to ensure protocol designs that are appropriate for institutional guidelines, USDA compliance and AALAC accreditation. The support staff are veterinary technologists or highly trained laboratory animal care personnel. Specialized equipment in this core is primarily connected with the housing and husbandry needs of the animals. For examples, VLAC has housing for upwards of 30,000 rodents in ventilated racks. The users of this facility are anyone involved in animal experimentation as well as numerous users from the pharmaceutical and biomedical device industry. Learn More Jerry K. Davis, Ph D. 765-494-1234
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